DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF133

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001374224.1	Gene:	ZNF133 / 7692	HGNCID:	12917	Length:	691	Species:	Homo sapiens

Alignment Length:	501	Identity:	145/501 - (28%)
Similarity:	209/501 - (41%)	Gaps:	107/501 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RRSVSKEDAVSLLTDSGISLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSK 69
            |:.||..:.:     .|:.|.:.| |:..:|..|..:.:|...|......|     .:.|...||
Human   209 RQPVSSRNGL-----RGVELEASP-AQSGNPEETDKLLKRIEVLGFGTVNC-----GECGLSFSK 262

  Fly    70 DDDYVQPQ-------------------LKKS------ARKGE-PV------------------KR 90
            ..:.:..|                   ||||      |..|| |:                  :|
Human   263 MTNLLSHQRIHSGEKPYVCGVCEKGFSLKKSLARHQKAHSGEKPIVCRECGRGFNRKSTLIIHER 327

  Fly    91 KH-----HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQF 150
            .|     ::||:|.:.|..|::|..|...||.|:|:.|::|||.:.|...:..|..| |...|..
Human   328 THSGEKPYMCSECGRGFSQKSNLIIHQRTHSGEKPYVCRECGKGFSQKSAVVRHQRT-HLEEKTI 391

  Fly   151 VCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSA 215
            |||.|...|:.:..|..|.|.|||||||.|..|.:.|.:...|..|..:|.|.  :.:.|..|..
Human   392 VCSDCGLGFSDRSNLISHQRTHSGEKPYACKECGRCFRQRTTLVNHQRTHSKE--KPYVCGVCGH 454

  Fly   216 SFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFE----CEICHKMIEP 276
            |||.|:.|..|...|.....:.|.:|...|    :|::|:|: |..:...|    |:.|.:....
Human   455 SFSQNSTLISHRRTHTGEKPYVCGVCGRGF----SLKSHLNR-HQNIHSGEKPIVCKDCGRGFSQ 514

  Fly   277 DEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIR 341
            ..:|..|.:.|:..|..||..|...|:|||....|.|.|:|||||.||.|.:.|:|.:.|..|.|
Human   515 QSNLIRHQRTHSGEKPMVCGECGRGFSQKSNLVAHQRTHSGERPYVCRECGRGFSHQAGLIRHKR 579

  Fly   342 KHTGEKPFRCQLC--------------------------EDEVAFSQLAHLKNHMKKIHKQQKPY 380
            ||:.|||:.|:.|                          |....|.|.:||..| :..|..:|||
Human   580 KHSREKPYMCRQCGLGFGNKSALITHKRAHSEEKPCVCRECGQGFLQKSHLTLH-QMTHTGEKPY 643

  Fly   381 MCEGCHDFFKIKVELQSH-----VEHCAKCPVDGD-KPSGNQSEDA 420
            :|:.|...|.:|..|..|     |.|  :.||..| :|...|..|:
Human   644 VCKTCGRGFSLKSHLSRHRKTTSVHH--RLPVQPDPEPCAGQPSDS 687

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/181 (31%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	5/19 (26%)
		COG5048	<192..369	CDD:227381	62/206 (30%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/48 (17%)
		C2H2 Zn finger	382..399	CDD:275368	6/21 (29%)
ZNF133	NP_001374224.1	KRAB	1..60	CDD:214630
		COG5048	252..661	CDD:227381	125/422 (30%)
		C2H2 Zn finger	253..273	CDD:275368	5/24 (21%)
		C2H2 Zn finger	281..301	CDD:275368	4/19 (21%)
		C2H2 Zn finger	309..329	CDD:275368	1/19 (5%)
		C2H2 Zn finger	337..357	CDD:275368	7/19 (37%)
		C2H2 Zn finger	365..385	CDD:275368	7/20 (35%)
		C2H2 Zn finger	393..413	CDD:275368	7/19 (37%)
		C2H2 Zn finger	421..441	CDD:275368	5/19 (26%)
		C2H2 Zn finger	449..469	CDD:275368	8/19 (42%)
		C2H2 Zn finger	477..497	CDD:275368	7/24 (29%)
		C2H2 Zn finger	505..525	CDD:275368	4/19 (21%)
		C2H2 Zn finger	533..553	CDD:275368	8/19 (42%)
		C2H2 Zn finger	561..581	CDD:275368	8/19 (42%)
		C2H2 Zn finger	589..609	CDD:275368	2/19 (11%)
		C2H2 Zn finger	617..637	CDD:275368	6/20 (30%)
		C2H2 Zn finger	645..664	CDD:275368	6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910