DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF90

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_009069.1	Gene:	ZNF90 / 7643	HGNCID:	13165	Length:	601	Species:	Homo sapiens

Alignment Length:	339	Identity:	113/339 - (33%)
Similarity:	172/339 - (50%)	Gaps:	12/339 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GEQDSKDDDYVQPQLKKS----ARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCK 124
            ||:..|.:| ...:||.|    |.|......|.:.|.:|.:.|...:.|..|.:.|::|:|:||:
Human   253 GEKRYKCED-CGKELKYSSTLTAHKRIHTGEKPYKCDKCGRAFISSSILYVHKISHTEEKPYKCE 316

  Fly   125 DCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFAR 189
            :|||:::.:..|..| ...|...|.:.|.:|.|:|.....||.|.|:|:|||||.||.|.|.|..
Human   317 ECGKAFKLSSILSTH-KRIHTGEKPYKCEECGKAFRRSLVLRTHKRIHTGEKPYKCDKCGKAFIS 380

  Fly   190 GGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAH 254
            ...|.:|.:||.:.  :.:.|.:|..:|..::.|.:|...|.:...::|..|:..|....||..|
Human   381 SSLLYKHKISHSEK--KPYKCEECGKAFKRSSTLTIHKISHTEEKPYKCQECDKVFKRSSALSTH 443

  Fly   255 INQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGER 319
             ...|.....::||.|.|..:...:|.||...||..|.:.|:.|:..|...|..:.|..:|:||.
Human   444 -KIIHSGEKPYKCEECGKAFKRSSNLTTHKISHTEEKLYKCQECDKAFKYSSALSTHKIIHSGEN 507

  Fly   320 PYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEG 384
            ||:|..|.:.|..||||..|...|||.||::|:.|..  ||.:.:.|.:| |..|..:|||.||.
Human   508 PYKCEECGKAFKRSSVLSKHKIIHTGAKPYKCEECGK--AFKRSSQLTSH-KISHTGEKPYKCEE 569

  Fly   385 CHDFFKIKVELQSH 398
            |...|.:..:|.:|
Human   570 CGKAFNLSSDLNTH 583

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/158 (32%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	15/23 (65%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	55/176 (31%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF90	NP_009069.1	KRAB	4..62	CDD:214630
		KRAB	6..43	CDD:279668
		COG5048	170..501	CDD:227381	78/252 (31%)
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368	6/20 (30%)
		zf-H2C2_2	272..296	CDD:290200	6/23 (26%)
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		zf-H2C2_2	300..323	CDD:290200	10/22 (45%)
		C2H2 Zn finger	315..335	CDD:275368	6/20 (30%)
		zf-H2C2_2	328..352	CDD:290200	8/24 (33%)
		C2H2 Zn finger	343..363	CDD:275368	8/19 (42%)
		zf-H2C2_2	356..380	CDD:290200	15/23 (65%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	5/19 (26%)
		C2H2 Zn finger	427..447	CDD:275368	6/20 (30%)
		zf-H2C2_2	439..464	CDD:290200	8/25 (32%)
		C2H2 Zn finger	455..475	CDD:275368	7/19 (37%)
		C2H2 Zn finger	483..503	CDD:275368	5/19 (26%)
		zf-H2C2_2	495..520	CDD:290200	9/24 (38%)
		C2H2 Zn finger	511..531	CDD:275368	8/19 (42%)
		zf-H2C2_2	524..548	CDD:290200	11/25 (44%)
		C2H2 Zn finger	539..559	CDD:275368	7/22 (32%)
		zf-H2C2_2	552..575	CDD:290200	10/23 (43%)
		C2H2 Zn finger	567..587	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000