DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF221

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001284517.1	Gene:	ZNF221 / 7638	HGNCID:	13014	Length:	617	Species:	Homo sapiens

Alignment Length:	392	Identity:	121/392 - (30%)
Similarity:	165/392 - (42%)	Gaps:	75/392 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 LKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITT 142
            |.:.:..||    |.|.|.:|.|.|.....|..|..:|..|:.:||..|||.:.|:.:|:.| ..
Human   187 LHQQSHSGE----KSHTCGECGKSFCYSPALHIHQRVHMGEKCYKCDVCGKEFNQSSHLQTH-QR 246

  Fly   143 AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQ 207
            .|...|.|.|.||.|.|..:..|.:|.:||:|||||.|:.|.|.|....|||:|...|  |..:.
Human   247 VHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYNCEECGKAFIHDSQLQEHQRIH--TGEKP 309

  Fly   208 FNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEIC-- 270
            |.|..|..||...:.|..|...|......||..|...|....||.:| :..|.:...::||.|
Human   310 FKCDICGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSH-SMVHIEEKPYKCEQCGK 373

  Fly   271 ----------HKMIEPDED----------------LATHMQRHTAVKTHVCEVCNTYFTQKSQ-- 307
                      |:|:...|.                |..|.|.|:..|:..||.|...|...|:
Human   374 GFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNHQQVHSGQKSFKCEECGKGFYTNSRRS 438

  Fly   308 -----------YN---------------VHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346
                       ||               .|.|:|||||||.|:.|.::|..:|.|..|.|.|:||
Human   439 SHQRSHNGEKPYNCEECGKDYKRRLDLEFHQRVHTGERPYNCKECGKSFGWASCLLKHQRLHSGE 503

  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE--------HCA 403
            |||:|:.|...  |:|.:.|.:| :..|..:|.|.||.|...:..|..|..|..        :|.
Human   504 KPFKCEECGKR--FTQSSQLHSH-QTCHTGEKLYKCEQCEKGYNSKFNLDMHQRVHGGERPYNCK 565

  Fly   404 KC 405
            :|
Human   566 EC 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/158 (36%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	67/232 (29%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	9/47 (19%)
		C2H2 Zn finger	295..315	CDD:275368	9/47 (19%)
		zf-H2C2_2	309..332	CDD:290200	13/37 (35%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF221	NP_001284517.1	KRAB	30..70	CDD:307490
		COG5048	166..576	CDD:227381	121/392 (31%)
		C2H2 Zn finger	172..192	CDD:275368	1/4 (25%)
		C2H2 Zn finger	200..220	CDD:275368	6/19 (32%)
		C2H2 Zn finger	228..248	CDD:275368	7/20 (35%)
		C2H2 Zn finger	256..276	CDD:275368	7/19 (37%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	6/20 (30%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	396..416	CDD:275368	3/19 (16%)
		C2H2 Zn finger	424..444	CDD:275368	5/19 (26%)
		C2H2 Zn finger	452..472	CDD:275368	2/19 (11%)
		C2H2 Zn finger	480..500	CDD:275368	7/19 (37%)
		C2H2 Zn finger	508..528	CDD:275368	6/22 (27%)
		C2H2 Zn finger	536..556	CDD:275368	6/19 (32%)
		C2H2 Zn finger	564..584	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910