DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF84

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001120844.1	Gene:	ZNF84 / 7637	HGNCID:	13159	Length:	738	Species:	Homo sapiens

Alignment Length:	367	Identity:	131/367 - (35%)
Similarity:	185/367 - (50%)	Gaps:	31/367 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 KKSARKGEPVKRKHH---------VCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAV 134
            |..:||.:.|  .||         .||.|.|.|..|::|.||..||:.|:|::|.:|.|::|:..
Human   354 KAFSRKSQLV--THHRTHTGTKPFGCSDCRKAFFEKSELIRHQTIHTGEKPYECSECRKAFRERS 416

  Fly   135 NLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVS 199
            :|.||..| |...|...|.||.|:|:.|..|..|...|:||||:.|..|.|.|:|..||.:|..:
Human   417 SLINHQRT-HTGEKPHGCIQCGKAFSQKSHLISHQMTHTGEKPFICSKCGKAFSRKSQLVRHQRT 480

  Fly   200 HHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQ 264
            |  |..:.:.|::|..:||...:|..|...|.....:.||.|...|..:..|.:| .:.|.....
Human   481 H--TGEKPYECSECGKAFSEKLSLTNHQRIHTGEKPYVCSECGKAFCQKSHLISH-QRTHTGEKP 542

  Fly   265 FECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQT 329
            :||..|.|.......||||.:.||..|.:.|..|...|:||||.|.|.|:||||:||:|.:|.:.
Human   543 YECSECGKAFGEKSSLATHQRTHTGEKPYECRDCEKAFSQKSQLNTHQRIHTGEKPYECSLCRKA 607

  Fly   330 FAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVE 394
            |...|.|..|:|.||||||:.|..|..  ||.:.:.|.|| ::||..:||:.|..|...|..|..
Human   608 FFEKSELIRHLRTHTGEKPYECNECRK--AFREKSSLINH-QRIHTGEKPFECSECGKAFSRKSH 669

  Fly   395 LQSHVE-HCAKCPVDGDKPSGNQ------SEDAQILSVLRFN 429
            |..|.. |      .|:||.|..      |:.:|:::..|.:
Human   670 LIPHQRTH------TGEKPYGCSECRKAFSQKSQLVNHQRIH 705

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	60/167 (36%)
		C2H2 Zn finger	95..115	CDD:275368	9/19 (47%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	64/176 (36%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	10/19 (53%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF84	NP_001120844.1	KRAB	9..68	CDD:214630
		C2H2 Zn finger	209..229	CDD:275368
		C2H2 Zn finger	237..257	CDD:275368
		C2H2 Zn finger	265..285	CDD:275368
		zf-H2C2_2	278..302	CDD:316026
		C2H2 Zn finger	293..313	CDD:275368
		COG5048	317..724	CDD:227381	131/367 (36%)
		C2H2 Zn finger	321..341	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368	6/16 (38%)
		C2H2 Zn finger	377..397	CDD:275368	9/19 (47%)
		C2H2 Zn finger	405..425	CDD:275368	8/20 (40%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..481	CDD:275368	8/19 (42%)
		C2H2 Zn finger	489..509	CDD:275368	6/19 (32%)
		C2H2 Zn finger	517..537	CDD:275368	6/20 (30%)
		C2H2 Zn finger	545..565	CDD:275368	7/19 (37%)
		C2H2 Zn finger	573..593	CDD:275368	10/19 (53%)
		C2H2 Zn finger	601..621	CDD:275368	7/19 (37%)
		C2H2 Zn finger	629..649	CDD:275368	7/22 (32%)
		C2H2 Zn finger	657..677	CDD:275368	6/19 (32%)
		C2H2 Zn finger	685..705	CDD:275368	3/19 (16%)
		C2H2 Zn finger	713..733	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000