DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF43

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001243582.1	Gene:	ZNF43 / 7594	HGNCID:	13109	Length:	818	Species:	Homo sapiens

Alignment Length:	329	Identity:	113/329 - (34%)
Similarity:	172/329 - (52%)	Gaps:	26/329 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|::|.:.|...::|.:|..||::::|:||::|||:::.:..|..|..| |...|.:.|.:|
Human   377 KFYKCTECGEAFSRSSNLTKHKKIHTEKKPYKCEECGKAFKWSSKLTEHKLT-HTGEKPYKCEEC 440

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|:|.....|..|.|:|:|||||.|::|.|.|.:...|..|...|  |:.:.:.|.:|..:||.:
Human   441 GKAFNWPSTLTKHNRIHTGEKPYKCEVCGKAFNQFSNLTTHKRIH--TAEKPYKCEECGKAFSRS 503

  Fly   221 ANLRVHMERHEQGMEHRCSICENQF--ANELALRAHINQEHHKLTQ-----FECEICHKMIEPDE 278
            :||..|.:.|.:...::|..|...|  :::|.        .||:|.     ::||.|.|......
Human   504 SNLTKHKKIHIEKKPYKCEECGKAFKWSSKLT--------EHKITHTGEKPYKCEECGKAFNHFS 560

  Fly   279 DLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKH 343
            .|..|.:.||..|.:.||.|...|||.|....|.::||||:.|:|..|.:.|..||.|..|.:.|
Human   561 ILTKHKRIHTGEKPYKCEECGKAFTQSSNLTTHKKIHTGEKFYKCEECGKAFTQSSNLTTHKKIH 625

  Fly   344 TGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVD 408
            ||.||::|:.|..  ||:|.:.|..| |.||.::|||.||.|...||....|..|     |....
Human   626 TGGKPYKCEECGK--AFNQFSTLTKH-KIIHTEEKPYKCEECGKAFKWSSTLTKH-----KIIHT 682

  Fly   409 GDKP 412
            |:||
Human   683 GEKP 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	51/157 (32%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/183 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	4/23 (17%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
ZNF43	NP_001243582.1	KRAB	13..72	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	158..177	CDD:275370
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		COG5048	295..763	CDD:227381	113/329 (34%)
		C2H2 Zn finger	297..317	CDD:275368
		zf-H2C2_2	309..333	CDD:290200
		C2H2 Zn finger	325..345	CDD:275368
		zf-H2C2_2	338..362	CDD:290200
		C2H2 Zn finger	353..373	CDD:275368
		C2H2 Zn finger	381..401	CDD:275368	5/19 (26%)
		zf-H2C2_2	393..417	CDD:290200	10/23 (43%)
		C2H2 Zn finger	409..429	CDD:275368	7/20 (35%)
		zf-H2C2_2	422..445	CDD:290200	8/23 (35%)
		C2H2 Zn finger	437..457	CDD:275368	7/19 (37%)
		zf-H2C2_2	450..474	CDD:290200	13/23 (57%)
		C2H2 Zn finger	465..485	CDD:275368	6/19 (32%)
		zf-H2C2_2	477..502	CDD:290200	7/26 (27%)
		C2H2 Zn finger	521..541	CDD:275368	6/27 (22%)
		zf-H2C2_2	534..558	CDD:290200	8/31 (26%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		zf-H2C2_2	562..586	CDD:290200	9/23 (39%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		zf-H2C2_2	589..614	CDD:290200	9/24 (38%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		zf-H2C2_2	617..642	CDD:290200	11/26 (42%)
		C2H2 Zn finger	633..653	CDD:275368	8/22 (36%)
		C2H2 Zn finger	661..681	CDD:275368	8/24 (33%)
		zf-H2C2_2	674..697	CDD:290200	6/18 (33%)
		C2H2 Zn finger	689..709	CDD:275368
		zf-H2C2_2	702..726	CDD:290200
		C2H2 Zn finger	717..737	CDD:275368
		zf-H2C2_2	729..754	CDD:290200
		COG5048	742..>803	CDD:227381
		C2H2 Zn finger	745..765	CDD:275368
		zf-H2C2_2	757..782	CDD:290200
		C2H2 Zn finger	773..793	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910