DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF33A

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001265106.1	Gene:	ZNF33A / 7581	HGNCID:	13096	Length:	832	Species:	Homo sapiens

Alignment Length:	357	Identity:	122/357 - (34%)
Similarity:	173/357 - (48%)	Gaps:	45/357 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRK 148
            |||    ||..|::|.|.|..|:.|.||..:|:.::|.:|.:|.|::....||..| ..:|...|
Human   345 KGE----KHFECNECGKAFWEKSHLTRHQRVHTGQKPFQCNECEKAFWDKSNLTKH-QRSHTGEK 404

  Fly   149 QFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKC 213
            .|.|::|.|:|:.|..|.||.|.|:|||||.|:.|.|.|.:...|.:|..:|  |.::.:.|.:|
Human   405 PFECNECGKAFSHKSALTLHQRTHTGEKPYQCNACGKTFCQKSDLTKHQRTH--TGLKPYECYEC 467

  Fly   214 SASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQE-----------HHK-- 261
            ..||...::|:||...|.......|..|...|:.:..|    |.||..:           :||
Human   468 GKSFRVTSHLKVHQRTHTGEKPFECLECGKSFSEKSNLTQHQRIHIGDKSYECNACGKTFYHKSL 532

  Fly   262 LTQ----------FECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHT 316
            ||:          :||..|.|......||..|.:.||..|...|..|..:|:.||..:.|.|.||
Human   533 LTRHQIIHTGWKPYECYECGKTFCLKSDLTVHQRTHTGQKPFACPECGKFFSHKSTLSQHYRTHT 597

  Fly   317 GERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYM 381
            ||:||:|..|.:.|.:.|.|..|.|.||||||:.|..|..  ||.|.:.|..| ::||..:|||.
Human   598 GEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGK--AFYQKSQLTQH-QRIHIGEKPYK 659

  Fly   382 CEGCHDFFKIK----VELQSHVEH----CAKC 405
            |..|...|..|    |..::|.:.    |.:|
Human   660 CNECGKAFCHKSALIVHQRTHTQEKPYKCNEC 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	8/24 (33%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	65/203 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/36 (19%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/20 (25%)
ZNF33A	NP_001265106.1	KRAB	33..92	CDD:214630
		KRAB	33..72	CDD:279668
		COG5048	163..537	CDD:227381	66/198 (33%)
		C2H2 Zn finger	324..344	CDD:275368
		C2H2 Zn finger	352..372	CDD:275368	8/19 (42%)
		zf-H2C2_2	364..388	CDD:290200	8/23 (35%)
		C2H2 Zn finger	380..400	CDD:275368	6/20 (30%)
		zf-H2C2_2	392..417	CDD:290200	10/25 (40%)
		C2H2 Zn finger	408..428	CDD:275368	9/19 (47%)
		zf-H2C2_2	420..443	CDD:290200	13/22 (59%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		COG5048	444..820	CDD:227381	79/253 (31%)
		zf-H2C2_2	448..471	CDD:290200	6/24 (25%)
		C2H2 Zn finger	464..484	CDD:275368	7/19 (37%)
		zf-H2C2_2	476..500	CDD:290200	6/23 (26%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	4/19 (21%)
		C2H2 Zn finger	548..568	CDD:275368	6/19 (32%)
		zf-H2C2_2	560..585	CDD:290200	9/24 (38%)
		C2H2 Zn finger	576..596	CDD:275368	7/19 (37%)
		zf-H2C2_2	589..611	CDD:290200	10/21 (48%)
		C2H2 Zn finger	604..624	CDD:275368	7/19 (37%)
		zf-H2C2_2	616..639	CDD:290200	11/24 (46%)
		C2H2 Zn finger	632..652	CDD:275368	7/22 (32%)
		zf-H2C2_2	645..667	CDD:290200	9/22 (41%)
		C2H2 Zn finger	660..680	CDD:275368	5/19 (26%)
		zf-H2C2_2	672..695	CDD:290200	4/20 (20%)
		C2H2 Zn finger	688..708	CDD:275368	2/4 (50%)
		C2H2 Zn finger	716..736	CDD:275368
		C2H2 Zn finger	744..764	CDD:275368
		zf-H2C2_2	756..781	CDD:290200
		C2H2 Zn finger	772..792	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910