DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF23

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001368913.1	Gene:	ZNF23 / 7571	HGNCID:	13023	Length:	686	Species:	Homo sapiens

Alignment Length:	346	Identity:	115/346 - (33%)
Similarity:	174/346 - (50%)	Gaps:	26/346 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 EEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKC 123
            |.:|.|:..:.:...:|.|   ....||    |.:.|::|.|.|...:.|::|..||:.|:|::|
Human   352 ECNDCGKAFNVNAKLIQHQ---RIHTGE----KPYECNECGKGFRCSSQLRQHQSIHTGEKPYQC 409

  Fly   124 KDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFA 188
            |:|||.:.....|..| ...|...|.:.|::|.|:|::|.:|..|.|:|:|||||.|:.|.|.|.
Human   410 KECGKGFNNNTKLIQH-QRIHTGEKPYECTECGKAFSVKGKLIQHQRIHTGEKPYECNECGKAFR 473

  Fly   189 RGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRA 253
            ...|.:||:..|  |..:.:.|.:|..:||.|..|..|...|.......|:.|...|.::..|
Human   474 CNSQFRQHLRIH--TGEKPYECNECGKAFSVNGKLMRHQRIHTGEKPFECNECGRCFTSKRNL-- 534

  Fly   254 HINQEHHKL----TQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRM 314
               .:||::    ..::|:.|.|....:..|..|.:.||..|...|..|...|:..|.|.||.|:
Human   535 ---LDHHRIHTGEKPYQCKECGKAFSINAKLTRHQRIHTGEKPFKCMECEKAFSCSSNYIVHQRI 596

  Fly   315 HTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQ--LAHLKNHMKKIHKQQ 377
            ||||:|:||:.|.:.|..::.|..|.|.|||||||||..|....:||.  :.|     :.:|..:
Human   597 HTGEKPFQCKECGKAFHVNAHLIRHQRSHTGEKPFRCVECGKGFSFSSDYIIH-----QTVHTWK 656

  Fly   378 KPYMCEGCHDFFKIKVELQSH 398
            |||||..|...|:...:|..|
Human   657 KPYMCSVCGKAFRFSFQLSQH 677

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/182 (33%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	5/24 (21%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF23	NP_001368913.1	KRAB	14..73	CDD:214630
		C2H2 Zn finger	185..205	CDD:275368
		C2H2 Zn finger	213..233	CDD:275368
		COG5048	229..649	CDD:227381	104/311 (33%)
		C2H2 Zn finger	241..261	CDD:275368
		C2H2 Zn finger	269..289	CDD:275368
		C2H2 Zn finger	297..317	CDD:275368
		C2H2 Zn finger	325..345	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368	4/22 (18%)
		C2H2 Zn finger	381..401	CDD:275368	6/19 (32%)
		C2H2 Zn finger	409..429	CDD:275368	7/20 (35%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..513	CDD:275368	7/19 (37%)
		C2H2 Zn finger	521..541	CDD:275368	6/24 (25%)
		C2H2 Zn finger	549..569	CDD:275368	5/19 (26%)
		C2H2 Zn finger	577..597	CDD:275368	8/19 (42%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		C2H2 Zn finger	633..653	CDD:275368	5/24 (21%)
		C2H2 Zn finger	661..681	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000