DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF17

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001317546.1	Gene:	ZNF17 / 7565	HGNCID:	12958	Length:	664	Species:	Homo sapiens

Alignment Length:	373	Identity:	120/373 - (32%)
Similarity:	176/373 - (47%)	Gaps:	27/373 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 LASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHV-----------CSQCSKE 101
            ||.....|:...:|..|:.|      :|.|...|..|  |.:..|.|           |:||.|:
Human   144 LAKRNLTCMQGGKDFTGDSD------LQQQALHSGWK--PHRDTHGVEAFQSGQNNYSCTQCGKD 200

  Fly   102 FGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLR 166
            |..:..|..|..||::|||::|.:|||.:|...:|..| ...|...:.:.||:|.|:|:||..:.
Human   201 FCHQHTLFEHQKIHTEERPYECSECGKLFRYNSDLIKH-QRNHTGERPYKCSECGKAFSLKYNVV 264

  Fly   167 LHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHE 231
            .|.::|:||:||.|..|.|.|.|...|.||...|  |..:.:.|::|..:|.|.|:|..|.:.|.
Human   265 QHQKIHTGERPYECSECGKAFLRKSHLLQHQRIH--TRPRPYVCSECGKAFLTQAHLVGHQKIHT 327

  Fly   232 QGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCE 296
            ....:.|:.|...|....||..| .:.|.....|.|..|.|.......|..|.:.||..|.:.|.
Human   328 GERPYGCNECGKYFMYSSALIRH-QKVHTGERPFYCCECGKFFMDSCTLIIHQRVHTGEKPYECN 391

  Fly   297 VCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFS 361
            .|..:|..:|....|.::||||:||:|..|.:.|..:|.|.:|.|.||||||:.|..|.   .|.
Human   392 ECGKFFRYRSTLIRHQKVHTGEKPYECSECGKFFMDTSTLIIHQRVHTGEKPYECNKCG---KFF 453

  Fly   362 QLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVD 408
            :.....|..:::|..::||.|..|..||.....|:||.. |..:.|.:
Human   454 RYCFTLNRHQRVHSGERPYECSECGKFFVDSCTLKSHQRVHTGERPFE 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	56/169 (33%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	4/22 (18%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
ZNF17	NP_001317546.1	KRAB	12..49	CDD:279668
		C2H2 Zn finger	151..180	CDD:275368	9/36 (25%)
		C2H2 Zn finger	194..214	CDD:275368	7/19 (37%)
		C2H2 Zn finger	222..242	CDD:275368	7/20 (35%)
		zf-H2C2_2	234..258	CDD:290200	7/24 (29%)
		COG5048	246..658	CDD:227381	87/262 (33%)
		C2H2 Zn finger	250..270	CDD:275368	8/19 (42%)
		zf-H2C2_2	262..287	CDD:290200	10/24 (42%)
		C2H2 Zn finger	278..298	CDD:275368	8/19 (42%)
		C2H2 Zn finger	306..326	CDD:275368	7/19 (37%)
		C2H2 Zn finger	334..354	CDD:275368	6/20 (30%)
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		C2H2 Zn finger	446..466	CDD:275368	4/22 (18%)
		zf-H2C2_2	459..482	CDD:290200	7/22 (32%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
		zf-H2C2_2	487..511	CDD:290200	5/15 (33%)
		C2H2 Zn finger	502..522	CDD:275368	120/373 (32%)
		zf-H2C2_2	515..539	CDD:290200
		C2H2 Zn finger	530..550	CDD:275368
		C2H2 Zn finger	558..578	CDD:275368
		C2H2 Zn finger	586..606	CDD:275368
		zf-H2C2_2	599..623	CDD:290200
		C2H2 Zn finger	614..634	CDD:275368
		zf-H2C2_2	626..651	CDD:290200
		C2H2 Zn finger	642..662	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000