DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF16

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001025147.2	Gene:	ZNF16 / 7564	HGNCID:	12947	Length:	682	Species:	Homo sapiens

Alignment Length:	356	Identity:	121/356 - (33%)
Similarity:	172/356 - (48%)	Gaps:	24/356 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 GEQDSKDDD----YVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCK 124
            ||.....||    :.|..:.|:..:.. :..|.:.||:|.|.|.|.:|..||...||.|||:.|.
Human   233 GEASFMCDDCGKTFSQNSVLKNRHRSH-MSEKAYQCSECGKAFRGHSDFSRHQSHHSSERPYMCN 296

  Fly   125 DCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFAR 189
            :|||::.|..:||.| ..:|...|.:.|::|.|:|.....|..|.|:|||||||.|..|.|.|.|
Human   297 ECGKAFSQNSSLKKH-QKSHMSEKPYECNECGKAFRRSSNLIQHQRIHSGEKPYVCSECGKAFRR 360

  Fly   190 GGQLQQHMVSHHKTSI--QQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALR 252
            ...|    :.||:|..  :.|.|.:|..:||.:|:||.|...|.....:.|:.|...|:....|.
Human   361 SSNL----IKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYECNDCGKPFSRVSNLI 421

  Fly   253 AHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTG 317
            .| ::.|.....::|..|.|.......|..|.:.||..|.|||.||...|:..|....|..:|||
Human   422 KH-HRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFSYSSVLRKHQIIHTG 485

  Fly   318 ERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMC 382
            |:||:|.:|.:.|:|||.|..|...|||:||:.|..|..  .|.:.::|..| :::|..:|||.|
Human   486 EKPYRCSVCGKAFSHSSALIQHQGVHTGDKPYACHECGK--TFGRSSNLILH-QRVHTGEKPYEC 547

  Fly   383 EGCHDFFKIKVELQSH--------VEHCAKC 405
            ..|...|.....|..|        ...|.:|
Human   548 TECGKTFSQSSTLIQHQRIHNGLKPHECNQC 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	61/160 (38%)
		C2H2 Zn finger	95..115	CDD:275368	9/19 (47%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	59/178 (33%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	5/24 (21%)
ZNF16	NP_001025147.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210
		COG5048	<160..369	CDD:227381	52/141 (37%)
		C2H2 Zn finger	187..203	CDD:275368
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368	4/19 (21%)
		C2H2 Zn finger	267..287	CDD:275368	9/19 (47%)
		Required for nuclear localization	268..393		52/129 (40%)
		C2H2 Zn finger	295..315	CDD:275368	8/20 (40%)
		COG5048	303..675	CDD:227381	96/285 (34%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		Required for nuclear localization	341..373		17/35 (49%)
		C2H2 Zn finger	351..371	CDD:275368	8/23 (35%)
		C2H2 Zn finger	379..399	CDD:275368	8/19 (42%)
		C2H2 Zn finger	407..427	CDD:275368	5/20 (25%)
		C2H2 Zn finger	435..455	CDD:275368	5/19 (26%)
		C2H2 Zn finger	463..483	CDD:275368	6/19 (32%)
		Required for nuclear localization	473..503		13/29 (45%)
		C2H2 Zn finger	491..511	CDD:275368	8/19 (42%)
		C2H2 Zn finger	519..539	CDD:275368	5/22 (23%)
		C2H2 Zn finger	547..567	CDD:275368	5/19 (26%)
		C2H2 Zn finger	575..595	CDD:275368	2/4 (50%)
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910