DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF708

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_016882693.1	Gene:	ZNF708 / 7562	HGNCID:	12945	Length:	587	Species:	Homo sapiens

Alignment Length:	351	Identity:	118/351 - (33%)
Similarity:	174/351 - (49%)	Gaps:	13/351 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAH 144
            |....||    |.:.|.:|.|.|...::|.:|.::|:.|:|:||::|||:::|:.||.|| ...|
Human   243 KIIHTGE----KLYKCEECGKAFNRSSNLTKHKIVHTGEKPYKCEECGKAFKQSSNLTNH-KKIH 302

  Fly   145 EHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFN 209
            ...|.:.|.:|.|:|.|...|..|.|:|:|||||.|:.|.|.|:....|.:|.:.|  |..:.:.
Human   303 TGEKPYKCGECGKAFTLSSHLTTHKRIHTGEKPYKCEECGKAFSVFSTLTKHKIIH--TEEKPYK 365

  Fly   210 CTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMI 274
            |.:|..:|:.:::|..|...|.....::|..|...|.....|..| ...|.....::||.|.|..
Human   366 CEECGKAFNRSSHLTNHKVIHTGEKPYKCEECGKAFTKSSTLTYH-KVIHTGKKPYKCEECGKAF 429

  Fly   275 EPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLH 339
            .....|..|...||..|.:.||.|...|...|.:..|.::||||:||:|..|.::|..||.|..|
Human   430 SIFSILTKHKVIHTEDKPYKCEECGKTFNYSSNFTNHKKIHTGEKPYKCEECGKSFILSSHLTTH 494

  Fly   340 IRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCA 403
            ...||||||::|:.|..  ||:|.:.|..| |.||..:|||.||.|...|.....|..|.. |..
Human   495 KIIHTGEKPYKCKECGK--AFNQSSTLMKH-KIIHTGEKPYKCEECGKAFNQSPNLTKHKRIHTK 556

  Fly   404 KCPVDGDKPSGNQSEDAQILSVLRFN 429
            :.|....:...| |::....|..:.|
Human   557 EKPYKSGRHHSN-SDNTSNFSKHKIN 581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/158 (34%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF708	XP_016882693.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000