DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF7

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001336738.1	Gene:	ZNF7 / 7553	HGNCID:	13139	Length:	707	Species:	Homo sapiens

Alignment Length:	403	Identity:	122/403 - (30%)
Similarity:	185/403 - (45%)	Gaps:	65/403 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSAR--KGE-PVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKN 138
            ||.:..|  .|| |.|     |::|.|.|...:.|.:|..||:.|:|::|::|||::.|:.:|.:
Human   285 QLNQHQRIHTGEKPFK-----CTECGKAFRLSSKLIQHQRIHTGEKPYRCEECGKAFGQSSSLIH 344

  Fly   139 HITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQH------- 196
            | ...|...:.:.|.:|.|:|:.:.:|..|.|.|:||:||||..|.|.|::...|.||
Human   345 H-QRIHTGERPYGCRECGKAFSQQSQLVRHQRTHTGERPYPCKECGKAFSQSSTLAQHQRMHTGE 408

  Fly   197 ------------MVSHHKTSI--QQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFAN 247
                        :|:|.:...  :.|.|.:|..:|...:.|..|...|.....::|:.|...|..
Human   409 KAQILKASDSPSLVAHQRIHAVEKPFKCDECGKAFRWISRLSQHQLIHTGEKPYKCNKCTKAFGC 473

  Fly   248 ELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHM 312
            ...|..| .:.|.....|:|:.|.|.......|..|.:.||..|.:||..|...|:|.|....|.
Human   474 SSRLIRH-QRTHTGEKPFKCDECGKGFVQGSHLIQHQRIHTGEKPYVCNDCGKAFSQSSSLIYHQ 537

  Fly   313 RMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQ 377
            |:|.||:||:|..|.:.|:.|:.|.:|.|.||||:|::|..|..  ||||.:.|..| :.||...
Human   538 RIHKGEKPYECLQCGKAFSMSTQLTIHQRVHTGERPYKCNECGK--AFSQNSTLFQH-QIIHAGV 599

  Fly   378 KPYMCEGCHDFF----------KIKVELQSHVEHCAKCPVDGDKPSGNQSEDAQILSVLRFNMAV 432
            |||.|..|...|          :|....|...|:            ||..|.:..:|
Human   600 KPYECSECGKAFSRSSYLIEHQRIHTRAQWFYEY------------GNALEGSTFVS-------- 644

  Fly   433 VLKKISSAQKLRQ 445
             .||:::.:||.|
Human   645 -RKKVNTIKKLHQ 656

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	51/179 (28%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	8/38 (21%)
		COG5048	<192..369	CDD:227381	59/197 (30%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/26 (19%)
ZNF7	NP_001336738.1	KRAB	25..86	CDD:214630
		PHA02693	64..>137	CDD:333460
		COG5048	239..696	CDD:227381	122/403 (30%)
		C2H2 Zn finger	246..265	CDD:275368
		C2H2 Zn finger	273..293	CDD:275368	3/7 (43%)
		C2H2 Zn finger	301..321	CDD:275368	6/19 (32%)
		C2H2 Zn finger	329..349	CDD:275368	7/20 (35%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	5/19 (26%)
		C2H2 Zn finger	464..484	CDD:275368	5/20 (25%)
		C2H2 Zn finger	492..512	CDD:275368	5/19 (26%)
		C2H2 Zn finger	520..540	CDD:275368	7/19 (37%)
		C2H2 Zn finger	548..568	CDD:275368	7/19 (37%)
		C2H2 Zn finger	576..596	CDD:275368	8/22 (36%)
		C2H2 Zn finger	604..624	CDD:275368	3/19 (16%)
		C2H2 Zn finger	657..677	CDD:275368	122/403 (30%)
		C2H2 Zn finger	685..705	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000