DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp74

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_848471.2	Gene:	Zfp74 / 72723	MGIID:	107784	Length:	679	Species:	Mus musculus

Alignment Length:	342	Identity:	123/342 - (35%)
Similarity:	172/342 - (50%)	Gaps:	27/342 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 KGEPVKRK---HH---------VCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNL 136
            ||...|.|   ||         .||:|.|.|...::|.||..||:.|:|:.|::||||:.|..||
Mouse   214 KGFSHKEKLINHHKLHSREQCYECSECGKTFIKMSNLIRHQRIHTGEKPYVCQECGKSFGQKSNL 278

  Fly   137 KNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHH 201
            .:| ...|...|.:.|::|.|||:.|:.|..|.::|:|||||.|:.|.|.|.|...|..||..|
Mouse   279 IDH-EKIHTGEKPYKCNECGKSFSQKQSLVAHQKVHTGEKPYACNECGKAFPRVASLALHMRGH- 341

  Fly   202 KTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFE 266
             |..:.:.|.||..:||..:.|.:|:..|.....:.|..|...|:...||..|| :.|.....:|
Mouse   342 -TGEKPYKCDKCGKAFSQFSMLIIHVRVHTGEKPYECGECGKAFSQSSALTVHI-RSHTGEKPYE 404

  Fly   267 CEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFA 331
            |:.|.|.....::..||.:.||..|.:.|..|...|.|.|....|.|:||||:||.|:.|.:.|:
Mouse   405 CKECRKSFSHKKNFITHQKIHTREKPYGCNECGKAFIQMSNLVRHQRIHTGEKPYLCKECGKAFS 469

  Fly   332 HSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFF----KIK 392
            ..|.|..|.:.|:||||:.|..|..  ||||..:...| :|:|..:|||.|..|...|    .:.
Mouse   470 QKSNLIAHEKIHSGEKPYECNECGK--AFSQKQNFITH-QKVHTGEKPYDCNKCGKAFSQIASLT 531

  Fly   393 VELQSHV----EHCAKC 405
            :.|:||.    ..|.||
Mouse   532 LHLRSHTGEKPYECEKC 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	62/170 (36%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	60/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/20 (25%)
Zfp74	NP_848471.2	KRAB	8..68	CDD:214630
		C2H2 Zn finger	181..201	CDD:275368
		COG5048	205..638	CDD:227381	123/342 (36%)
		C2H2 Zn finger	209..229	CDD:275368	6/14 (43%)
		C2H2 Zn finger	237..257	CDD:275368	8/19 (42%)
		C2H2 Zn finger	265..285	CDD:275368	9/20 (45%)
		C2H2 Zn finger	293..313	CDD:275368	8/19 (42%)
		C2H2 Zn finger	321..341	CDD:275368	8/19 (42%)
		C2H2 Zn finger	349..369	CDD:275368	7/19 (37%)
		C2H2 Zn finger	377..397	CDD:275368	7/20 (35%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		C2H2 Zn finger	489..509	CDD:275368	8/22 (36%)
		C2H2 Zn finger	517..537	CDD:275368	4/19 (21%)
		C2H2 Zn finger	545..565	CDD:275368	3/4 (75%)
		C2H2 Zn finger	573..593	CDD:275368
		C2H2 Zn finger	601..621	CDD:275368
		C2H2 Zn finger	629..649	CDD:275368
		zf-H2C2_2	641..666	CDD:372612
		C2H2 Zn finger	657..677	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000