DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp639

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001155290.1	Gene:	Zfp639 / 67778	MGIID:	1915028	Length:	485	Species:	Mus musculus

Alignment Length:	357	Identity:	92/357 - (25%)
Similarity:	151/357 - (42%)	Gaps:	73/357 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 EEEDDGGE--QDSKDDDYVQPQLK--KSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDE 118
            |.|::..|  ||..|:   :|..|  |...||:.:    :|.:|           |:..|:.::.
Mouse   154 EAENNSSESLQDQADE---EPPAKLCKILDKGQAL----NVTAQ-----------QKWPLLRANS 200

  Fly   119 RP-HKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDL 182
            .. :||:.|..:.:...:||.|:...|:.....||..|.:||:....|..|.:||. |.||.|..
Mouse   201 SGLYKCELCEFNSKYFSDLKQHVILKHKRTDSNVCRVCKESFSTNMLLIEHAKLHE-EDPYICKY 264

  Fly   183 CDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFAN 247
            ||.|......|.||:...| .|...:.|.:|...||:::.|.:|.:.|.:..::.|..||::..:
Mouse   265 CDYKTVIFENLSQHIADTH-FSDHLYWCEQCDVQFSSSSELYLHFQEHSRDEQYLCQFCEHETGD 328

  Fly   248 ELALRAHINQEH----------------------HKLT------QFECEICHKMIEPDEDLATHM 284
            ...|.:|:..||                      .|:|      .|.|::|...    ..|.|::
Mouse   329 PEDLHSHVVNEHARRLIELSDKCGSGGHGQCSLLSKITFDKCKNFFVCQVCGFR----SRLHTNV 389

  Fly   285 QRHTAVK-----THVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIR-KH 343
            .||.|::     .|||:.|...|:...:|..|:..|..|..|.|:.|..:......||:|:. ||
Mouse   390 NRHVAIEHTKIFPHVCDDCGKGFSSMLEYCKHLNSHLSEGIYLCQYCEYSTGQIDDLKIHLDFKH 454

  Fly   344 TGEKPFRCQLC------EDEVAFSQLAHLKNH 369
            :.:.|.:|..|      |.::    |.||:.|
Mouse   455 SADLPHKCSECLMRFGNERDL----LGHLQVH 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	42/159 (26%)
		C2H2 Zn finger	95..115	CDD:275368	3/19 (16%)
		zf-H2C2_2	107..132	CDD:290200	5/25 (20%)
		C2H2 Zn finger	123..144	CDD:275368	5/20 (25%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	53/216 (25%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	7/43 (16%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	6/22 (27%)
		C2H2 Zn finger	323..343	CDD:275368	5/20 (25%)
		C2H2 Zn finger	351..374	CDD:275368	7/25 (28%)
		C2H2 Zn finger	382..399	CDD:275368
Zfp639	NP_001155290.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	54..80
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	115..136
		C2H2 Zn finger	235..255	CDD:275368	6/19 (32%)
		C2H2 Zn finger	262..283	CDD:275368	7/20 (35%)
		C2H2 Zn finger	291..307	CDD:275368	5/15 (33%)
		Interaction with CTNNA2. /evidence=ECO:0000250	371..455		24/87 (28%)
		C2H2 Zn finger	376..397	CDD:275368	7/24 (29%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		zf-C2H2_8	408..481	CDD:406359	21/76 (28%)
		C2H2 Zn finger	433..454	CDD:275368	5/20 (25%)
		C2H2 Zn finger	462..482	CDD:275368	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950