DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp442

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011238043.1	Gene:	Zfp442 / 668923	MGIID:	3651999	Length:	673	Species:	Mus musculus

Alignment Length:	349	Identity:	117/349 - (33%)
Similarity:	174/349 - (49%)	Gaps:	37/349 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHIT 141
            |..|....||    |.:.|:||.|.|..:..|:||..||:.|:|:||..|||.:.|:.:...|..
Mouse   317 QQHKRTHTGE----KSYECNQCDKAFALRCHLRRHQRIHTVEKPYKCNQCGKFFAQSNHFVRHKR 377

  Fly   142 T---------------------------AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYP 179
            |                           .|...|.:||::|.|:|.|:..|::|.|.|:||||:.
Mouse   378 THTGEKPYECNQCDKAFACQTSLLYHKRTHSGEKLYVCNECGKAFVLQSYLQIHKRTHTGEKPFG 442

  Fly   180 CDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQ 244
            ||.|||.||:...|..|..:|  |..:.:.|.:|..:|::|:||:||.:.|.....:.|..|...
Mouse   443 CDQCDKAFAQNSHLLTHKRTH--TGEKPYECEQCGKAFASNSNLQVHKKTHTGEKPYECKQCGKA 505

  Fly   245 FANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYN 309
            |..:..|:.| .:.|.....:||..|.|.......|..|.:.||..|.:.|..|...|...|...
Mouse   506 FGFQSGLQKH-KRTHTGEKPYECNQCDKAFACQASLLNHKRSHTGEKPYECSECGKAFVLHSYLQ 569

  Fly   310 VHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIH 374
            :|.|:||||:|::|..|.:.||.:::|..|.|.|||:||:.|:.|..  ||:..::|:.| |:.|
Mouse   570 IHKRIHTGEKPFECDQCDKAFARNTLLLKHKRIHTGQKPYGCKQCGK--AFANHSNLQVH-KRTH 631

  Fly   375 KQQKPYMCEGCHDFFKIKVELQSH 398
            ..:|||.|:.|...||.:..||.|
Mouse   632 TGEKPYECKHCGKPFKCQSGLQYH 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	60/185 (32%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/47 (15%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	7/17 (41%)
Zfp442	XP_011238043.1	KRAB	10..50	CDD:366587
		C2H2 Zn finger	83..103	CDD:275368
		C2H2 Zn finger	140..159	CDD:275368
		C2H2 Zn finger	167..183	CDD:275368
		C2H2 Zn finger	191..211	CDD:275368
		COG5048	215..595	CDD:227381	91/284 (32%)
		C2H2 Zn finger	219..239	CDD:275368
		C2H2 Zn finger	247..267	CDD:275368
		C2H2 Zn finger	275..295	CDD:275368
		C2H2 Zn finger	303..323	CDD:275368	2/5 (40%)
		C2H2 Zn finger	331..351	CDD:275368	8/19 (42%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		C2H2 Zn finger	387..407	CDD:275368	0/19 (0%)
		C2H2 Zn finger	415..435	CDD:275368	8/19 (42%)
		C2H2 Zn finger	443..463	CDD:275368	9/19 (47%)
		C2H2 Zn finger	471..491	CDD:275368	8/19 (42%)
		C2H2 Zn finger	499..519	CDD:275368	5/20 (25%)
		C2H2 Zn finger	527..547	CDD:275368	5/19 (26%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		SFP1	<577..660	CDD:227516	33/82 (40%)
		C2H2 Zn finger	583..603	CDD:275368	7/19 (37%)
		C2H2 Zn finger	611..631	CDD:275368	7/22 (32%)
		C2H2 Zn finger	639..658	CDD:275368	7/17 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910