DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Gm14391

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001092778.1	Gene:	Gm14391 / 665001	MGIID:	3709324	Length:	554	Species:	Mus musculus

Alignment Length:	457	Identity:	140/457 - (30%)
Similarity:	198/457 - (43%)	Gaps:	87/457 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KSARKGEPVK---RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHIT 141
            :|.|:...:|   .|||.|:||.|:|.....||.|...|:.|:|:.||.|||.:.::.:|:.|..
Mouse    87 ESGRQRHQIKHNGEKHHDCNQCGKDFRTWNVLQIHKRTHTGEKPYDCKQCGKVFARSCHLQIHNR 151

  Fly   142 TAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
            | |...||:.|:||.|:...:..|::|.|.|:|||||.|:.|.|.||..|.||||..:|  |..:
Mouse   152 T-HAGEKQYECNQCGKALKRRSDLQIHKRTHTGEKPYECNQCGKAFASSGDLQQHKRTH--TGEK 213

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAH----------------- 254
            .:.|.:|..:||..::||:|...|.....:.|..|...||:...|..|
Mouse   214 PYECKQCGKAFSECSHLRIHKRTHTGEKPYECKQCGKAFAHSSHLHKHERTHTGDKPYECNQCGK 278

  Fly   255 ----------------------INQ-----------EHHKLTQ-----FECEICHKMIEPDEDLA 281
                                  .||           :.||.|.     :||..|.|.......|.
Mouse   279 AFAVIYTLQMHKRTHTGDKPYECNQCGKAFAVIYTLQMHKRTHTGDKPYECNQCGKAFAVIYTLQ 343

  Fly   282 THMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346
            .|.|.||..|.:.|:.|...||:.....:|.|.||||:||:|..|.:.||.|..|:.|.|.||||
Mouse   344 RHKQTHTGEKPYKCKQCGKAFTRSCHLRIHKRTHTGEKPYECNQCGKAFARSGDLQKHKRTHTGE 408

  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCPVDGD 410
            ||:.|:.|..  ||:..:||..| ::.|...|||.|..|...|.....||.|.. |      .|:
Mouse   409 KPYECKQCGK--AFAHSSHLHKH-ERTHTGDKPYECNQCGKAFAESSTLQIHNRTH------TGE 464

  Fly   411 KP-SGNQSEDAQILSVLRFNMAVVLKKISSAQKLRQLG---YEKRLIDNVIIASLKLAQ-RQSHD 470
            || ..||.           ..|.:.:::....|....|   ||.:.......:|..|.: :::|.
Mouse   465 KPYECNQC-----------GKAFITRRVLQIHKRTHTGEKPYECKQCGKAFASSSDLQKHKRTHS 518

  Fly   471 DA 472
            .|
Mouse   519 GA 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	62/161 (39%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	10/19 (53%)
		COG5048	<192..369	CDD:227381	67/231 (29%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	8/71 (11%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Gm14391	NP_001092778.1	KRAB	3..44	CDD:366587
		C2H2 Zn finger	79..97	CDD:275368	2/9 (22%)
		C2H2 Zn finger	105..125	CDD:275368	8/19 (42%)
		COG5048	129..515	CDD:227381	122/408 (30%)
		C2H2 Zn finger	133..153	CDD:275368	8/20 (40%)
		C2H2 Zn finger	161..181	CDD:275368	7/19 (37%)
		C2H2 Zn finger	189..209	CDD:275368	10/19 (53%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		C2H2 Zn finger	273..293	CDD:275368	0/19 (0%)
		C2H2 Zn finger	301..321	CDD:275368	4/19 (21%)
		C2H2 Zn finger	329..349	CDD:275368	6/19 (32%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		C2H2 Zn finger	385..405	CDD:275368	8/19 (42%)
		C2H2 Zn finger	413..433	CDD:275368	7/22 (32%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		C2H2 Zn finger	469..489	CDD:275368	4/30 (13%)
		C2H2 Zn finger	497..517	CDD:275368	2/19 (11%)
		zf-H2C2_2	509..534	CDD:372612	3/12 (25%)
		C2H2 Zn finger	525..545	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000