DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZFP69B

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_005271193.1	Gene:	ZFP69B / 65243	HGNCID:	28053	Length:	535	Species:	Homo sapiens

Alignment Length:	342	Identity:	101/342 - (29%)
Similarity:	156/342 - (45%)	Gaps:	53/342 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 ESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCS 96
            |..||| :.:.|::           |.:.|..|::...:.|.|.       ......|.|...|:
Human   238 EVMPGP-IGLPRKR-----------DRKYDTPGKRSRYNIDLVN-------HSRSYTKMKTFECN 283

  Fly    97 QCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFAL 161
            .|.|.|.....|..||.||:.|:|.:||:|||::.|:.:|..| ...|...|.:.|.:|.|:|..
Human   284 ICEKIFKQLIHLTEHMRIHTGEKPFRCKECGKAFSQSSSLIPH-QRIHTGEKPYECKECGKTFRH 347

  Fly   162 KERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVH 226
            ...|..|:|:|:|||||.|.:|:|.|::...|.||:.:|.:.  :.|.|..|..:|....:||.|
Human   348 PSSLTQHVRIHTGEKPYECRVCEKAFSQSIGLIQHLRTHVRE--KPFTCKDCGKAFFQIRHLRQH 410

  Fly   227 MERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVK 291
            ...|.....:.|::|...|::..           .|||                  |.:.||..:
Human   411 EIIHTGVKPYICNVCSKTFSHST-----------YLTQ------------------HQRTHTGER 446

  Fly   292 THVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCED 356
            .:.|:.|...|:|:...::|.|:|||.:||:|..|.:.|.|.|....|.|.||||||:.|..|..
Human   447 PYKCKECGKAFSQRIHLSIHQRVHTGVKPYECSHCGKAFRHDSSFAKHQRIHTGEKPYDCNECGK 511

  Fly   357 EVAFSQ--LAHLKNHMK 371
            ..:.|.  :.|.|.|::
Human   512 AFSCSSSLIRHCKTHLR 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	50/178 (28%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	3/21 (14%)
		C2H2 Zn finger	267..287	CDD:275368	1/19 (5%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	6/23 (26%)
		C2H2 Zn finger	382..399	CDD:275368
ZFP69B	XP_005271193.1	SCAN	<2..40	CDD:383046
		KRAB	74..134	CDD:214630
		COG5048	<194..430	CDD:227381	64/213 (30%)
		C2H2 Zn finger	258..274	CDD:275368	3/22 (14%)
		C2H2 Zn finger	282..302	CDD:275368	7/19 (37%)
		C2H2 Zn finger	310..330	CDD:275368	8/20 (40%)
		C2H2 Zn finger	338..358	CDD:275368	7/19 (37%)
		C2H2 Zn finger	366..386	CDD:275368	7/19 (37%)
		C2H2 Zn finger	394..414	CDD:275368	6/19 (32%)
		C2H2 Zn finger	422..442	CDD:275368	7/48 (15%)
		zf-H2C2_2	434..459	CDD:372612	9/42 (21%)
		C2H2 Zn finger	450..470	CDD:275368	6/19 (32%)
		zf-H2C2_2	462..487	CDD:372612	10/24 (42%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:372612	10/24 (42%)
		C2H2 Zn finger	506..526	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910