DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZNF723

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_024307421.1	Gene:	ZNF723 / 646864	HGNCID:	32286	Length:	547	Species:	Homo sapiens

Alignment Length:	473	Identity:	139/473 - (29%)
Similarity:	202/473 - (42%)	Gaps:	83/473 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VSKEDAVSLLTDSGIS---------LSSPPA-----ARESSPGPTLAIKRRKSSLAS-------- 50
            |||.|.::.| :.|..         ::.||.     |::..|...:....:|..|.|
Human    47 VSKPDLITCL-EQGKEPWNMKRHKMVAKPPVVCSHFAQDLWPEQGIKDSFQKVILRSYGKYGHDN 110

  Fly    51 --LRDAC--VDE-EEDDGGEQDSKD------------DDYVQPQLKKSARKGEPVK--------- 89
              ||..|  ||| :...||..:.|.            |.||:...|.|:...:.::
Human   111 LQLRKGCESVDECKMHKGGYDELKQCLTTTPSKIFQCDKYVKVFHKFSSSNSQKIRHTGNNSFKC 175

  Fly    90 -----------------RKH-----HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQ 132
                             |.|     :.|.:|.|.|...:.|..|..||:.|:|:||::|||::..
Human   176 KECGKSFCMLSHLTKHERNHTRVNCYKCEECGKAFSVPSKLNNHKRIHTGEKPYKCEECGKAFNV 240

  Fly   133 AVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHM 197
            :.:|.|| ...|...|.:.|.:|.|:|.:...|..|.|:|:|||||.|..|.|.|.....|..|.
Human   241 SSSLNNH-KRIHTGEKPYKCEECGKTFNMFSSLNNHKRIHTGEKPYKCKECGKAFNVFSSLNNHK 304

  Fly   198 VSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKL 262
            ..|  |..:.:.|.:|..:|:..::|..|...|.....::|..|...|:....:..| .:.|...
Human   305 RIH--TGEKPYKCEECGKAFNQPSHLATHKRIHTGEKLYKCEECGKAFSQSSHITTH-KRIHTGE 366

  Fly   263 TQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICH 327
            ..::||.|.|..:....|.||.:.||..|.:.||.|...|.|.|....|..:|||||||:|:.|.
Human   367 KPYKCEECGKAFKVSVHLTTHKRIHTGEKPYKCEECGKAFNQSSALTTHKIIHTGERPYKCKQCG 431

  Fly   328 QTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIK 392
            :.|:.||.|..|...||.|||::|:.|..  ||:|.:.|..| |.||.::|||.||.|...|...
Human   432 KGFSQSSTLTKHKIIHTKEKPYKCEECGK--AFNQYSTLNKH-KIIHAREKPYKCEECGKAFNKS 493

  Fly   393 VELQSH-----VEHCAKC 405
            ..|..|     .|...||
Human   494 SILNRHKIIHTKEKSQKC 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/189 (28%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/21 (29%)
ZNF723	XP_024307421.1	KRAB	4..64	CDD:214630	6/17 (35%)
		COG5048	156..504	CDD:227381	111/354 (31%)
		C2H2 Zn finger	175..195	CDD:275368	1/19 (5%)
		C2H2 Zn finger	203..223	CDD:275368	6/19 (32%)
		C2H2 Zn finger	231..251	CDD:275368	7/20 (35%)
		C2H2 Zn finger	259..279	CDD:275368	7/19 (37%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..363	CDD:275368	4/20 (20%)
		C2H2 Zn finger	371..391	CDD:275368	7/19 (37%)
		C2H2 Zn finger	399..419	CDD:275368	7/19 (37%)
		C2H2 Zn finger	427..447	CDD:275368	7/19 (37%)
		C2H2 Zn finger	455..475	CDD:275368	8/22 (36%)
		C2H2 Zn finger	483..503	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000