DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZFP62

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001166109.1	Gene:	ZFP62 / 643836	HGNCID:	23241	Length:	900	Species:	Homo sapiens

Alignment Length:	333	Identity:	116/333 - (34%)
Similarity:	165/333 - (49%)	Gaps:	12/333 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAH 144
            ||...||    |:..|.:|.|.|...:.|.:|..||:.|:|::|.:|||::|.:..|:.| ...|
Human   216 KSTHSGE----KNCKCDECGKSFNYSSVLDQHKRIHTGEKPYECGECGKAFRNSSGLRVH-KRIH 275

  Fly   145 EHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFN 209
            ...|.:.|..|.|:|:....||:|.|:|:|||||.||.|.|.|.....|..|...|.  ..:.:.
Human   276 TGEKPYECDICGKTFSNSSGLRVHKRIHTGEKPYECDECGKAFITCRTLLNHKSIHF--GDKPYK 338

  Fly   210 CTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMI 274
            |.:|..||:.::.|..|...|.....:.|..|...|.|...|..| .:.|.....::|::|.|..
Human   339 CDECEKSFNYSSLLIQHKVIHTGEKPYECDECGKAFRNSSGLIVH-KRIHTGEKPYKCDVCGKAF 402

  Fly   275 EPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLH 339
            .....||.|...|...|.|.|:.|...|:..|....|..:|||||||.|.:|.:||.:::.||:|
Human   403 SYSSGLAVHKSIHPGKKAHECKECGKSFSYNSLLLQHRTIHTGERPYVCDVCGKTFRNNAGLKVH 467

  Fly   340 IRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCA 403
            .|.||||||::|.:|..  |:...:.|||| |.||..:|||.|..|...|.....|:.|.. |..
Human   468 RRLHTGEKPYKCDVCGK--AYISRSSLKNH-KGIHLGEKPYKCSYCEKSFNYSSALEQHKRIHTR 529

  Fly   404 KCPVDGDK 411
            :.|...|:
Human   530 EKPFGCDE 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/158 (33%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	15/23 (65%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZFP62	NP_001166109.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..97
		COG5048	125..552	CDD:227381	116/333 (35%)
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368	2/2 (100%)
		C2H2 Zn finger	227..247	CDD:275368	6/19 (32%)
		C2H2 Zn finger	255..275	CDD:275368	7/20 (35%)
		C2H2 Zn finger	283..303	CDD:275368	8/19 (42%)
		C2H2 Zn finger	311..331	CDD:275368	7/19 (37%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..387	CDD:275368	6/20 (30%)
		C2H2 Zn finger	395..415	CDD:275368	6/19 (32%)
		C2H2 Zn finger	423..443	CDD:275368	5/19 (26%)
		COG5048	447..860	CDD:227381	38/94 (40%)
		C2H2 Zn finger	451..471	CDD:275368	8/19 (42%)
		C2H2 Zn finger	479..499	CDD:275368	8/22 (36%)
		C2H2 Zn finger	507..527	CDD:275368	5/19 (26%)
		C2H2 Zn finger	535..555	CDD:275368	1/3 (33%)
		C2H2 Zn finger	563..583	CDD:275368
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		C2H2 Zn finger	647..667	CDD:275368
		C2H2 Zn finger	675..695	CDD:275368
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	731..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..834	CDD:275368
		C2H2 Zn finger	842..862	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910