DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and PRDM15

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_011527985.1	Gene:	PRDM15 / 63977	HGNCID:	13999	Length:	1441	Species:	Homo sapiens

Alignment Length:	650	Identity:	137/650 - (21%)
Similarity:	204/650 - (31%)	Gaps:	247/650 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 SKEDAVSLLTDSGISLSSPPAARESSPGPTLAIKR-----RKSSLASLRDACVDEEEDDGGEQDS 68
            |:.:|.:...:.......|||..||....|...|:     ||..::......|..|:.:..||.:
Human   530 SQSEAAAPEKEQDTPRGEPPAVPESENVATKEQKKKPRRGRKPKVSKAEQPLVIVEDKEPTEQVA 594

  Fly    69 KDDDYVQPQLKKSARKGEPV-------------------KRKHH--------------------- 93
            :....|.|....||...|.:                   |..||
Human   595 EIITEVPPDEPVSATPDERIMELVLGKLATTTTDTSSVPKFTHHQNNTITLKRSLILSSRHGIRR 659

  Fly    94 -------------VCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAH- 144
                         .|:.|||.|...::|.||:..|.| :..||::|.|.:.:..:||.|::..|
Human   660 KLIKQLGEHKRVYQCNICSKIFQNSSNLSRHVRSHGD-KLFKCEECAKLFSRKESLKQHVSYKHS 723

  Fly   145 ------EHR----------------------------------------------------KQFV 151
                  |:|                                                    |:|.
Human   724 RNEVDGEYRYRCGTCEKTFRIESALEFHNCRTDDKTFQCEMCFRFFSTNSNLSKHKKKHGDKKFA 788

  Fly   152 CSQCPKSFALKERLRLHMRLH-------------------------------------------- 172
            |..|.|.|..|:.:..|.|.|
Human   789 CEVCSKMFYRKDVMLDHQRRHLEGVRRVKREDLEAGGENLVRYKKEPSGCPVCGKVFSCRSNMNK 853

  Fly   173 ----SGEKPYPCDLCDKKFARGGQLQQHMVSHHK------------------------------- 202
                .|:|.|.|::|.:||.|...|:.|:..|.|
Human   854 HLLTHGDKKYTCEICGRKFFRVDVLRDHIHVHFKDIALMDDHQREEFIGKIGISSEENDDNSDES 918

  Fly   203 --TSIQQFNCTKCSASFSTNANLRVH-MERH-EQGMEHRCSICENQFANELALRAHINQEHHKLT 263
              :...:::|.:|..:|........| ||.| |:|  :.||||..:||.:....||:......|.
Human   919 ADSEPHKYSCKRCQLTFGRGKEYLKHIMEVHKEKG--YGCSICNRRFALKATYHAHMVIHRENLP 981

  Fly   264 Q-------FECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMR-------- 313
            .       ..||||.::.....:|..|...||.||:|.||.|...|.:|.....|||
Human   982 DPNVQKYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNVREY 1046

  Fly   314 --------------------MHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEV 358
                                :|.|.:.|:|:.||:.||....:..|.::|||.|.|.|:||..
Human  1047 LCAECGKGMKTKHALRHHMKLHKGIKEYECKECHRRFAQKVNMLKHCKRHTGIKDFMCELCGK-- 1109

  Fly   359 AFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE------HCAKCPVDGDKPSGNQS 417
            .||:...::.| |.||...|.:.|..|...:..:..||.||:      ....|.:.|.|.|...|
Human  1110 TFSERNTMETH-KLIHTVGKQWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRAS 1173

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	59/353 (17%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	10/71 (14%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	60/246 (24%)
		C2H2 Zn finger	210..230	CDD:275370	6/20 (30%)
		C2H2 Zn finger	238..260	CDD:275371	8/21 (38%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/47 (17%)
		zf-H2C2_2	309..332	CDD:290200	10/50 (20%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
PRDM15	XP_011527985.1	SET	349..465	CDD:214614
		GAGA_bind	<515..>580	CDD:283799	11/49 (22%)
		COG5048	663..1125	CDD:227381	101/467 (22%)
		zf-C2H2	672..694	CDD:278523	8/21 (38%)
		C2H2 Zn finger	674..694	CDD:275368	8/19 (42%)
		C2H2 Zn finger	701..722	CDD:275368	6/20 (30%)
		C2H2 Zn finger	735..751	CDD:275368	0/15 (0%)
		C2H2 Zn finger	789..809	CDD:275368	7/19 (37%)
		C2H2 Zn finger	838..858	CDD:275368	0/19 (0%)
		C2H2 Zn finger	865..885	CDD:275368	7/19 (37%)
		C2H2 Zn finger	928..949	CDD:275370	6/20 (30%)
		C2H2 Zn finger	956..976	CDD:275368	8/19 (42%)
		C2H2 Zn finger	992..1012	CDD:275368	6/19 (32%)
		zf-H2C2_2	1004..1029	CDD:290200	11/24 (46%)
		C2H2 Zn finger	1020..1040	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1048..1068	CDD:275368	0/19 (0%)
		zf-H2C2_2	1060..1085	CDD:290200	7/24 (29%)
		C2H2 Zn finger	1076..1096	CDD:275368	6/19 (32%)
		C2H2 Zn finger	1104..1124	CDD:275368	7/22 (32%)
		C2H2 Zn finger	1132..1153	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910