DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp997

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001171303.1	Gene:	Zfp997 / 628709	MGIID:	3642406	Length:	604	Species:	Mus musculus

Alignment Length:	376	Identity:	131/376 - (34%)
Similarity:	175/376 - (46%)	Gaps:	23/376 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKH-----HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRK 148
            ||.|     :.|:||.|.|...::|:.|...|:.|:|::|..|||::.:..:|:.|..| |...|
Mouse   122 KRNHTGERPYECNQCGKAFSSHSNLRYHKRTHTGEKPYECNQCGKAFARPADLQYHKRT-HTGEK 185

  Fly   149 QFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKC 213
            .:.|:||.|:|:....||.|.|.|:|||||.|:.|.|.|||...||.|..:|  |..:.:.|.:|
Mouse   186 PYECNQCGKAFSCHSGLRYHKRTHTGEKPYECNQCGKAFARPADLQYHKRTH--TGEKPYECNQC 248

  Fly   214 SASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDE 278
            ..:||.::.||.|...|.....:.|:.|...|:....||.| .:.|.....|||..|.|......
Mouse   249 GKAFSCHSGLRYHKRTHTGEKPYECNQCGKAFSCHSGLRYH-KRTHTGEKPFECNQCGKAFSSHS 312

  Fly   279 DLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKH 343
            .|..|.:.||..|.:.|..|...|........|.|.||||:||:|..|.:.||.||.|:.|.|.|
Mouse   313 GLRYHKRTHTGEKPYECNQCGKSFATSRHLQCHKRTHTGEKPYECNQCGKAFATSSHLQCHKRTH 377

  Fly   344 TGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-------- 400
            |||||:.|..|..  |||..:.|::| |:.|..:|||.|..|...|.....||.|..
Mouse   378 TGEKPYECNQCGK--AFSCHSGLRHH-KRTHTGEKPYECNQCGKAFSRPAYLQHHKRTHTGEKPY 439

  Fly   401 HCAKCPVDGDKPSGNQSEDAQILSVLRFNMAVVLKKISSAQKLRQLGYEKR 451
            .|.:|.....|||..|...........|......|..|....||   |.||
Mouse   440 ECNQCGKAFAKPSHLQCHKRTHTGEKPFECNQCGKAFSCYNSLR---YHKR 487

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	59/162 (36%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	9/19 (47%)
		COG5048	<192..369	CDD:227381	62/176 (35%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Zfp997	NP_001171303.1	KRAB	4..>46	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	77..97	CDD:275368
		zf-H2C2_2	89..114	CDD:290200
		C2H2 Zn finger	105..125	CDD:275368	2/2 (100%)
		zf-H2C2_2	118..142	CDD:290200	8/19 (42%)
		COG5048	129..564	CDD:227381	128/369 (35%)
		C2H2 Zn finger	133..153	CDD:275368	7/19 (37%)
		zf-H2C2_2	145..170	CDD:290200	9/24 (38%)
		C2H2 Zn finger	161..181	CDD:275368	7/20 (35%)
		zf-H2C2_2	173..198	CDD:290200	10/25 (40%)
		C2H2 Zn finger	189..209	CDD:275368	9/19 (47%)
		zf-H2C2_2	202..226	CDD:290200	14/23 (61%)
		C2H2 Zn finger	217..237	CDD:275368	9/19 (47%)
		zf-H2C2_2	229..254	CDD:290200	8/26 (31%)
		C2H2 Zn finger	245..265	CDD:275368	7/19 (37%)
		zf-H2C2_2	258..282	CDD:290200	7/23 (30%)
		C2H2 Zn finger	273..293	CDD:275368	6/20 (30%)
		zf-H2C2_2	286..310	CDD:290200	9/24 (38%)
		C2H2 Zn finger	301..321	CDD:275368	5/19 (26%)
		zf-H2C2_2	314..338	CDD:290200	8/23 (35%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		zf-H2C2_2	341..366	CDD:290200	11/24 (46%)
		C2H2 Zn finger	357..377	CDD:275368	9/19 (47%)
		zf-H2C2_2	369..394	CDD:290200	13/26 (50%)
		C2H2 Zn finger	385..405	CDD:275368	8/22 (36%)
		zf-H2C2_2	398..422	CDD:290200	10/24 (42%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		zf-H2C2_2	425..449	CDD:290200	5/23 (22%)
		C2H2 Zn finger	441..461	CDD:275368	6/19 (32%)
		zf-H2C2_2	453..478	CDD:290200	3/24 (13%)
		C2H2 Zn finger	469..489	CDD:275368	7/22 (32%)
		C2H2 Zn finger	497..517	CDD:275368
		zf-H2C2_2	509..534	CDD:290200
		C2H2 Zn finger	525..545	CDD:275368
		C2H2 Zn finger	553..573	CDD:275368
		zf-H2C2_2	565..590	CDD:290200
		C2H2 Zn finger	581..601	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000