DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF317

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_065984.3	Gene:	ZNF317 / 57693	HGNCID:	13507	Length:	595	Species:	Homo sapiens

Alignment Length:	517	Identity:	143/517 - (27%)
Similarity:	206/517 - (39%)	Gaps:	135/517 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SRRSVSKE---DAVSLLTDSGISLSSPP----AARESSPGPTLAIKRRKSSLASLRDACVDEE-- 59
            |:|.:.|:   :..|.||..|..:..|.    ..:|..|        |.....:.:.||.|.|
Human    77 SQRKLYKDVMLENYSNLTSLGYQVGKPSLISHLEQEEEP--------RTEERGAHQGACADWETP 133

  Fly    60 ---------EDDGGEQ------------DSKDDDY--------VQPQLKKS-------------- 81
                     ||..|::            ..|..:|        :.|.|.:.
Human   134 SKTKWSLLMEDIFGKETPSGVTMERAGLGEKSTEYAHLFEVFGMDPHLTQPMGRHAGKRPYHRRD 198

  Fly    82 ---ARKGEP---------VKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAV 134
               |.||.|         ..||.|.|.||.|.|.....|.||..||:.|:|::|.||||::....
Human   199 YGVAFKGRPHLTQHMSMYDGRKMHECHQCQKAFTTSASLTRHRRIHTGEKPYECSDCGKAFNDPS 263

  Fly   135 NLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARG--------- 190
            .|::|..| |...|.|.||||..:|.....|::|||:|:||:||.||.|.|.:.|.
Human   264 ALRSHART-HLKEKPFDCSQCGNAFRTLSALKIHMRVHTGERPYKCDQCGKAYGRSCHLIAHKRT 327

  Fly   191 -------------------GQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEH 236
                               ..|::|:.:|  |..:.:.||:|..:|...:|..:|.:.|.....:
Human   328 HTGERPYECHDCGKAFQHPSHLKEHVRNH--TGEKPYACTQCGKAFRWKSNFNLHKKNHMVEKTY 390

  Fly   237 RCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTY 301
            .|..|...|.:.::.|.|: :.|......||..|.|.......|.|||..||..|.:.|::|...
Human   391 ECKECGKSFGDLVSRRKHM-RIHIVKKPVECRQCGKTFRNQSILKTHMNSHTGEKPYGCDLCGKA 454

  Fly   302 FTQKSQYNVHMRMHTGERPY----------------------------QCRICHQTFAHSSVLKL 338
            |:..|....|.::||.||.|                            :||.|.:.|.:.|.||.
Human   455 FSASSNLTAHRKIHTQERRYECAACGKVFGDYLSRRRHMSVHLVKKRVECRQCGKAFRNQSTLKT 519

  Fly   339 HIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE 400
            |:|.||||||:.|..|..  |||..::|..| ::||..:|||.|..|...|.....|:|||:
Human   520 HMRSHTGEKPYECDHCGK--AFSIGSNLNVH-RRIHTGEKPYECLVCGKAFSDHSSLRSHVK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	59/186 (32%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/47 (15%)
		COG5048	<192..369	CDD:227381	59/204 (29%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	10/50 (20%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF317	NP_065984.3	KRAB	57..109	CDD:214630	8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		4/26 (15%)
		COG5048	222..580	CDD:227381	115/364 (32%)
		C2H2 Zn finger	224..244	CDD:275368	8/19 (42%)
		C2H2 Zn finger	252..272	CDD:275368	8/20 (40%)
		C2H2 Zn finger	280..300	CDD:275368	9/19 (47%)
		C2H2 Zn finger	308..328	CDD:275368	5/19 (26%)
		C2H2 Zn finger	336..356	CDD:275368	2/19 (11%)
		C2H2 Zn finger	364..384	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	5/20 (25%)
		C2H2 Zn finger	420..440	CDD:275368	7/19 (37%)
		C2H2 Zn finger	448..468	CDD:275368	5/19 (26%)
		C2H2 Zn finger	476..496	CDD:275368	0/19 (0%)
		C2H2 Zn finger	504..524	CDD:275368	9/19 (47%)
		C2H2 Zn finger	532..552	CDD:275368	7/22 (32%)
		C2H2 Zn finger	560..580	CDD:275368	7/19 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910