DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and Zfp111

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_030098675.1	Gene:	Zfp111 / 56707	MGIID:	1929114	Length:	731	Species:	Mus musculus

Alignment Length:	438	Identity:	136/438 - (31%)
Similarity:	193/438 - (44%)	Gaps:	85/438 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 QLKKSARKGEPVKRKHHVCSQCSKEFG----------------------GK-----TDLQRHMLI 114
            |..|....||    |.:.|..|.|.|.                      ||     .:...|..:
Mouse   312 QAHKRIHTGE----KPYKCGDCGKRFSCISNFHIHQRVHTKSKPSKCDYGKPFNLRCNFHSHQRV 372

  Fly   115 HSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYP 179
            |:.|:|:||::|||.:..|.:.:.| ...|...|.||||.|.|.|:....|:.|.|:|||:|||.
Mouse   373 HTGEKPYKCEECGKGFTSASSFQRH-QRVHTGEKPFVCSVCGKGFSRTSYLQTHQRVHSGDKPYQ 436

  Fly   180 CDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQ 244
            ||.|.|.|.:...||.|...|  |..:.:.|..|...||.::||..|...|.....::|..|...
Mouse   437 CDSCGKGFTQLSHLQAHERIH--TDQKPYKCGDCGKRFSCSSNLHTHQRVHTGEKPYKCEECGKG 499

  Fly   245 FANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYN 309
            |:....|:||...|..| ..|:|..|.|......:|..|.:.||..|.:.|:.|...|.|:|...
Mouse   500 FSLVSGLQAHQRVETGK-KPFKCNACQKRFSQAWNLHAHQRVHTGEKPYKCDTCGKAFGQRSGLQ 563

  Fly   310 VHM----------------------------RMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGE 346
            :|.                            |:||||:||:|:.|.:.|:.:|.|:.|.|.||||
Mouse   564 IHQRIHTGEKPFKCEECGKEFSLNSGLIAHRRVHTGEKPYECKDCGKGFSLASSLRTHQRVHTGE 628

  Fly   347 KPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGDK 411
            |||:|..|:..  |||::||::| :::|..:|||.|:.|...|..|..||.|     |....|:|
Mouse   629 KPFQCNECQKR--FSQVSHLQSH-QRVHTGEKPYKCDRCGKAFSQKSGLQVH-----KRIHTGEK 685

  Fly   412 P-----SGNQSEDAQILSVLRFNMAVVLKKISSAQK-LRQLGYEKRLI 453
            |     .|.:...:..||..|        |:.:.:| .|:..|.|.||
Mouse   686 PFKCEECGKEFIWSSGLSAHR--------KVHTGEKPYRRRQYGKGLI 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/185 (31%)
		C2H2 Zn finger	95..115	CDD:275368	7/46 (15%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	64/204 (31%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/47 (15%)
		zf-H2C2_2	309..332	CDD:290200	11/50 (22%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
Zfp111	XP_030098675.1	KRAB	39..79	CDD:366587
		COG5048	<148..425	CDD:227381	32/117 (27%)
		C2H2 Zn finger	242..262	CDD:275368
		C2H2 Zn finger	270..290	CDD:275368
		C2H2 Zn finger	298..318	CDD:275368	2/5 (40%)
		C2H2 Zn finger	326..346	CDD:275368	4/19 (21%)
		C2H2 Zn finger	354..373	CDD:275368	3/18 (17%)
		COG5048	377..>672	CDD:227381	103/301 (34%)
		C2H2 Zn finger	381..401	CDD:275368	6/20 (30%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		C2H2 Zn finger	437..457	CDD:275368	8/19 (42%)
		C2H2 Zn finger	465..485	CDD:275368	7/19 (37%)
		C2H2 Zn finger	493..512	CDD:275368	6/18 (33%)
		C2H2 Zn finger	521..541	CDD:275368	5/19 (26%)
		C2H2 Zn finger	549..569	CDD:275368	6/19 (32%)
		C2H2 Zn finger	577..597	CDD:275368	1/19 (5%)
		C2H2 Zn finger	605..625	CDD:275368	7/19 (37%)
		C2H2 Zn finger	633..653	CDD:275368	8/22 (36%)
		C2H2 Zn finger	661..681	CDD:275368	8/24 (33%)
		zf-H2C2_2	674..696	CDD:372612	8/26 (31%)
		C2H2 Zn finger	689..709	CDD:275368	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000