DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11247 and ZKSCAN7

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001275519.1	Gene:	ZKSCAN7 / 55888	HGNCID:	12955	Length:	754	Species:	Homo sapiens

Alignment Length:	537	Identity:	151/537 - (28%)
Similarity:	219/537 - (40%)	Gaps:	135/537 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRSRRSVSKEDAV--------------------SLLTDSGISLSSPPAARESSPGPTLAIKRR- 44
            |||.:.:|:.||..                    :::.::..|::| .|......|..|..|:.
Human   224 MVRPQDTVAYEDLSVDYTQKKWKSLTLSQRALQWNMMPENHHSMAS-LAGENMMKGSELTPKQEF 287

  Fly    45 -KSSLASLR----------------DACVD----------EEE------------DDGGEQDSKD 70
             |.|.:|.|                |.|.|          :||            |:..::.:||
Human   288 FKGSESSNRTSGGLFGVVPGAAETGDVCEDTFKELEGQTSDEEGSRLENDFLEITDEDKKKSTKD 352

  Fly    71 --DDYVQ----PQLKKSARKGEPVKR--KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCG 127
              |.|.:    |.|..|..:.|.|.:  |.:.|.:|.|.|...:.|..|..||:.|:|::|.:||
Human   353 RYDKYKEVGEHPPLSSSPVEHEGVLKGQKSYRCDECGKAFNRSSHLIGHQRIHTGEKPYECNECG 417

  Fly   128 KSYRQAVNLKNHITT---------------------------AHEHRKQFVCSQCPKSFALKERL 165
            |::||...|..|:.|                           .|...|.:.|::|.|:|....||
Human   418 KTFRQTSQLIVHLRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRL 482

  Fly   166 RLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERH 230
            ..|.|.|:|||||.|:.|.:.|.|...|.:|.|.|  |..:.:.|.:|..:|.:|.||..|...|
Human   483 TDHQRTHTGEKPYECNECGEAFIRSKSLARHQVLH--TGKKPYKCNECGRAFCSNRNLIDHQRIH 545

  Fly   231 EQGMEHRCSICENQFANELALRAH------------------INQ-----EHHKL----TQFECE 268
            .....:.||.|...|:....|..|                  .||     ||.::    ..|||.
Human   546 TGEKPYECSECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLIEHERIHTGEKPFECS 610

  Fly   269 ICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHS 333
            .|.|.....:.|..|.:.||..|.:.|..|...|.|.|...:|.|:||||:||:|..|.:.|::|
Human   611 ECGKAFGLSKCLIRHQRLHTGEKPYKCNECGKSFNQNSHLIIHQRIHTGEKPYECNECGKVFSYS 675

  Fly   334 SVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            |.|.:|.|.||||||::|..|..  |||..:.|..| :::|..:|||.|..|...|..:.....|
Human   676 SSLMVHQRTHTGEKPYKCNDCGK--AFSDSSQLIVH-QRVHTGEKPYECSECGKAFSQRSTFNHH 737

  Fly   399 VE-HCAKCPVDGDKPSG 414
            .. |      .|:|.||
Human   738 QRTH------TGEKSSG 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/187 (31%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/47 (19%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	66/203 (33%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	9/44 (20%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	3/16 (19%)
ZKSCAN7	NP_001275519.1	SCAN	51..161	CDD:128708
		SCAN	51..138	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..215
		KRAB_A-box	231..270	CDD:143639	5/39 (13%)
		COG5048	380..738	CDD:227381	114/362 (31%)
		zf-C2H2	383..405	CDD:278523	6/21 (29%)
		C2H2 Zn finger	385..405	CDD:275368	6/19 (32%)
		zf-H2C2_2	401..422	CDD:290200	9/20 (45%)
		C2H2 Zn finger	413..433	CDD:275368	8/19 (42%)
		zf-H2C2_2	426..450	CDD:290200	3/23 (13%)
		C2H2 Zn finger	441..461	CDD:275368	0/19 (0%)
		zf-H2C2_2	453..478	CDD:290200	6/24 (25%)
		C2H2 Zn finger	469..489	CDD:275368	8/19 (42%)
		zf-H2C2_2	482..506	CDD:290200	12/23 (52%)
		C2H2 Zn finger	497..517	CDD:275368	7/19 (37%)
		zf-H2C2_2	509..532	CDD:290200	7/24 (29%)
		C2H2 Zn finger	525..545	CDD:275368	7/19 (37%)
		zf-H2C2_2	537..562	CDD:290200	8/24 (33%)
		C2H2 Zn finger	553..573	CDD:275368	6/19 (32%)
		zf-H2C2_2	566..590	CDD:290200	2/23 (9%)
		C2H2 Zn finger	581..601	CDD:275368	4/19 (21%)
		zf-H2C2_2	594..616	CDD:290200	7/21 (33%)
		C2H2 Zn finger	609..629	CDD:275368	5/19 (26%)
		zf-H2C2_2	622..646	CDD:290200	8/23 (35%)
		C2H2 Zn finger	637..657	CDD:275368	7/19 (37%)
		zf-H2C2_2	649..674	CDD:290200	11/24 (46%)
		C2H2 Zn finger	665..685	CDD:275368	8/19 (42%)
		zf-H2C2_2	677..701	CDD:290200	12/25 (48%)
		C2H2 Zn finger	693..713	CDD:275368	7/22 (32%)
		zf-H2C2_2	706..730	CDD:290200	9/24 (38%)
		C2H2 Zn finger	721..741	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..754		6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910