DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZSCAN2

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_024305746.1	Gene:	ZSCAN2 / 54993	HGNCID:	20994	Length:	645	Species:	Homo sapiens

Alignment Length:	495	Identity:	147/495 - (29%)
Similarity:	208/495 - (42%)	Gaps:	100/495 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VRSRRSVSKEDAVSLLTDSGISLSSPPAARESSPGPTLAI-------KRRKSSL----------- 48
            ::..|..|.|:|.:|:.|...:|....:.|...|...|.:       .||...|
Human   110 LQEHRPESSEEAAALVEDLTQTLQDSGSQRVHQPFSVLTVCKVSSRSARRALELHLNYFEIQSEN 174

  Fly    49 -------------------------ASLRDACVDEEED-------------DGGEQDSKDDD--- 72
                                     |...|...|.|.|             |.||..|:|.:
Human   175 GENCNQDMFENESRKIFSEMPEGESAQHSDGESDFERDAGIQRLQGHSPGEDHGEVVSQDREVGQ 239

  Fly    73 -------------YVQPQLKKS-ARKGEPVK-------RKHHVCSQCSKEFGGKTDLQRHMLIHS 116
                         |..||..|: :||...:.       .|::.|.:|.|.|...::..||...|:
Human   240 LIGLQGTYLGEKPYECPQCGKTFSRKSHLITHERTHTGEKYYKCDECGKSFSDGSNFSRHQTTHT 304

  Fly   117 DERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCD 181
            .|:|:||:|||||:.::.||..| ...|...|.|.|::|.|||:....|..|.|.|:|||||.|.
Human   305 GEKPYKCRDCGKSFSRSANLITH-QRIHTGEKPFQCAECGKSFSRSPNLIAHQRTHTGEKPYSCP 368

  Fly   182 LCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFA 246
            .|.|.|.....|..|...|  |..:.:.|.:|..|||.|:||..|...|.....::|:.|..:|:
Human   369 ECGKSFGNRSSLNTHQGIH--TGEKPYECKECGESFSYNSNLIRHQRIHTGEKPYKCTDCGQRFS 431

  Fly   247 NELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVH 311
            ...||..| .:.|.....::|..|.|......:||||.:.|...|.:.|.||...|:|.|....|
Human   432 QSSALITH-RRTHTGEKPYQCSECGKSFSRSSNLATHRRTHMVEKPYKCGVCGKSFSQSSSLIAH 495

  Fly   312 MRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQ 376
            ..|||||:||:|..|.::|:.||.|..|.|.||||||::|..|..  .|||.:.|..| ::.|..
Human   496 QGMHTGEKPYECLTCGESFSWSSNLLKHQRIHTGEKPYKCSECGK--CFSQRSQLVVH-QRTHTG 557

  Fly   377 QKPYMCEGCHDFFK----IKVELQSHVEHCAKCPVDGDKP 412
            :|||.|..|...|.    :.:..::|:         ||||
Human   558 EKPYKCLMCGKSFSRGSILVMHQRAHL---------GDKP 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/165 (35%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	64/176 (36%)
		C2H2 Zn finger	210..230	CDD:275370	9/19 (47%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	3/20 (15%)
ZSCAN2	XP_024305746.1	SCAN	70..157	CDD:322011	10/46 (22%)
		COG5048	251..631	CDD:227381	124/354 (35%)
		C2H2 Zn finger	255..275	CDD:275368	5/19 (26%)
		C2H2 Zn finger	283..303	CDD:275368	6/19 (32%)
		C2H2 Zn finger	311..331	CDD:275368	9/20 (45%)
		C2H2 Zn finger	339..359	CDD:275368	8/19 (42%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	9/19 (47%)
		C2H2 Zn finger	423..443	CDD:275368	6/20 (30%)
		C2H2 Zn finger	451..471	CDD:275368	7/19 (37%)
		C2H2 Zn finger	479..499	CDD:275368	7/19 (37%)
		C2H2 Zn finger	507..527	CDD:275368	8/19 (42%)
		C2H2 Zn finger	535..555	CDD:275368	7/22 (32%)
		C2H2 Zn finger	563..583	CDD:275368	3/19 (16%)
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910