DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF727

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001152994.1	Gene:	ZNF727 / 442319	HGNCID:	22785	Length:	499	Species:	Homo sapiens

Alignment Length:	355	Identity:	107/355 - (30%)
Similarity:	162/355 - (45%)	Gaps:	28/355 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCS 153
            :.|.:.|.:|.|:. ..:|......||:.:|.:||::|||:.::..||..| ...|..:|.:.|.
Human   169 REKCYKCEECGKDC-RLSDFTIQKRIHTADRSYKCEECGKACKKFSNLTEH-NRVHTGKKPYKCE 231

  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218
            :|.|:|.....|..|.|.|:|::||.|:.|.|.|.....|.:|...|  |..:.:.|.:|..:|.
Human   232 ECGKTFTCSSALTKHKRNHTGDRPYKCEECHKAFRCCSDLTKHKRIH--TGEKPYKCKECHKAFR 294

  Fly   219 TNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATH 283
            ..::|..|...|.....::|:.|...|....||..| |:.|.....:.||.|.|.......|.:|
Human   295 CCSDLTKHKRIHTGEKPYKCNECGKAFMWISALSQH-NRIHTGEKPYICEECGKAFTYSSTLISH 358

  Fly   284 MQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKP 348
            .:.|..::.:.||.|...|...|....|.|:||||:||:|..|.::|..||.|..|.|.|...:|
Human   359 KRIHMELRPYKCEECGKTFKWFSDLTNHKRIHTGEKPYKCEECGKSFTCSSNLIKHKRIHMEVRP 423

  Fly   349 FRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGDKPS 413
            ::|:.|..  .|.....|.|| |:||..:|||.||.|...|.....|..|     |....||:|:
Human   424 YKCEECGK--TFKWFPDLTNH-KRIHTGEKPYKCEECGKTFTCSSSLIKH-----KRSHTGDRPT 480

  Fly   414 GNQSEDAQILSVLRFNMAVVLKKISSAQKL 443
            ..::               |.|.:..:|.|
Human   481 SAKN---------------VAKPLGGSQTL 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	46/157 (29%)
		C2H2 Zn finger	95..115	CDD:275368	4/19 (21%)
		zf-H2C2_2	107..132	CDD:290200	9/24 (38%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	52/176 (30%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF727	NP_001152994.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	148..167	CDD:275370
		C2H2 Zn finger	175..194	CDD:275368	4/19 (21%)
		C2H2 Zn finger	202..222	CDD:275368	7/20 (35%)
		zf-H2C2_2	214..239	CDD:290200	9/25 (36%)
		COG5048	<226..409	CDD:227381	57/185 (31%)
		C2H2 Zn finger	230..250	CDD:275368	7/19 (37%)
		zf-H2C2_2	242..267	CDD:290200	11/24 (46%)
		C2H2 Zn finger	258..278	CDD:275368	6/19 (32%)
		zf-H2C2_2	270..295	CDD:290200	7/26 (27%)
		C2H2 Zn finger	286..306	CDD:275368	5/19 (26%)
		zf-H2C2_2	298..321	CDD:290200	5/22 (23%)
		C2H2 Zn finger	314..334	CDD:275368	7/20 (35%)
		zf-H2C2_2	326..351	CDD:290200	9/25 (36%)
		C2H2 Zn finger	342..362	CDD:275368	6/19 (32%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		zf-H2C2_2	382..407	CDD:290200	11/24 (46%)
		C2H2 Zn finger	398..418	CDD:275368	8/19 (42%)
		C2H2 Zn finger	426..446	CDD:275368	7/22 (32%)
		zf-H2C2_2	438..463	CDD:290200	13/25 (52%)
		C2H2 Zn finger	454..474	CDD:275368	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000