DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp708

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001012325.2	Gene:	Zfp708 / 432769	MGIID:	3040674	Length:	541	Species:	Mus musculus

Alignment Length:	317	Identity:	109/317 - (34%)
Similarity:	160/317 - (50%)	Gaps:	8/317 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|...:....|...||.|:|::||||||::....||..| ...|...|.:.|.:|
Mouse   231 KPYKCGECGKAFTIYSTFMNHQRTHSGEKPYECKDCGKAFTNCYNLIQH-QRIHTGEKPYACEEC 294

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTN 220
            .|||.....|:.|.|:|:|||||.|::|.|.|.....|.:|...|  |..:.:.|..|..:||.:
Mouse   295 GKSFNYSSHLKQHKRIHTGEKPYKCEVCGKAFNCSDYLVKHQRIH--TGEKPYKCEVCGKAFSFS 357

  Fly   221 ANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQ 285
            ..|..|...|.....:||..|...|.|...|..| .:.|.....::||.|.|.......|:.|.:
Mouse   358 TYLHKHQRIHTGEKRYRCEECGKAFTNYSGLIVH-RRVHTGEKPYKCEECGKAFSVHTSLSKHQR 421

  Fly   286 RHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFR 350
            .||..:.:.|:.|...|:..|.::.|..|||.|:||:|:.|.:||.:.|.|..|.|.||||:|::
Mouse   422 IHTREQPYKCDECGKTFSVHSTFSKHQIMHTREKPYKCKHCDKTFKYPSPLVQHERIHTGERPYK 486

  Fly   351 CQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCP 406
            |::|..  ||:..::||.|. ::|..:|||.||.|...||....:..|.: |..:.|
Mouse   487 CEVCGK--AFTSSSNLKYHW-RLHTGEKPYKCEQCGKAFKNSSNVTRHYKIHTRENP 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/155 (35%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Zfp708	NP_001012325.2	KRAB	17..77	CDD:214630
		KRAB	17..56	CDD:279668
		C2H2 Zn finger	95..115	CDD:275368
		COG5048	119..540	CDD:227381	108/315 (34%)
		C2H2 Zn finger	123..143	CDD:275368
		zf-H2C2_2	136..160	CDD:290200
		C2H2 Zn finger	151..171	CDD:275368
		C2H2 Zn finger	179..199	CDD:275368
		zf-H2C2_2	191..216	CDD:290200
		C2H2 Zn finger	207..227	CDD:275368
		zf-H2C2_2	219..243	CDD:290200	4/11 (36%)
		C2H2 Zn finger	235..255	CDD:275368	5/19 (26%)
		zf-H2C2_2	248..272	CDD:290200	11/23 (48%)
		C2H2 Zn finger	263..283	CDD:275368	9/20 (45%)
		zf-H2C2_2	275..300	CDD:290200	10/25 (40%)
		C2H2 Zn finger	291..311	CDD:275368	8/19 (42%)
		zf-H2C2_2	303..328	CDD:290200	13/24 (54%)
		C2H2 Zn finger	319..339	CDD:275368	6/19 (32%)
		zf-H2C2_2	331..355	CDD:290200	6/25 (24%)
		C2H2 Zn finger	347..367	CDD:275368	6/19 (32%)
		C2H2 Zn finger	375..395	CDD:275368	6/20 (30%)
		zf-H2C2_2	388..411	CDD:290200	7/23 (30%)
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		zf-H2C2_2	415..439	CDD:290200	6/23 (26%)
		C2H2 Zn finger	431..451	CDD:275368	5/19 (26%)
		C2H2 Zn finger	459..479	CDD:275368	8/19 (42%)
		zf-H2C2_2	472..496	CDD:290200	12/25 (48%)
		C2H2 Zn finger	487..507	CDD:275368	7/22 (32%)
		C2H2 Zn finger	515..535	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000