DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF749

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001018855.2	Gene:	ZNF749 / 388567	HGNCID:	32783	Length:	778	Species:	Homo sapiens

Alignment Length:	429	Identity:	118/429 - (27%)
Similarity:	190/429 - (44%)	Gaps:	91/429 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGK--SYRQAVNLKNHITTAHEHRKQFVCS 153
            :.:.||:|.|.|.....|.||..:|:.|||.:|..|||  |:|..:|:...:   |..::.:.||
Human   352 RRYECSECGKLFMDSFTLGRHQRVHTGERPFECSICGKFFSHRSTLNMHQRV---HAGKRLYKCS 413

  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQH-------------MVSHHKTSI 205
            :|.|:|:||..:..|:::|:||:||.|..|:|.|.|...|.||             ::.|.:..|
Human   414 ECGKAFSLKHNVVQHLKIHTGERPYECTECEKAFVRKSHLVQHQKIHTDAFSKRSDLIQHKRIDI 478

  Fly   206 --QQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL----------------- 251
              :.:.|::|..:|.|.|:|..|.:.|.....:.|:.|...|..:..|
Human   479 RPRPYTCSECGKAFLTQAHLVGHQKIHTGERPYECTQCAKAFVRKSHLVQHEKIHTDAFSKRSDL 543

  Fly   252 -------------------RAHINQEH---HKLTQ-----FECEICHKMIEPDEDLATHMQRHTA 289
                               :|.:.|.|   |:..|     :||..|.|.......|..|.:.||.
Human   544 IQHKRIDLRPRPYVCSECGKAFLTQAHLDGHQKIQTGERRYECNECGKFFLDSYKLVIHQRIHTG 608

  Fly   290 VKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC 354
            .|.:.|..|..:|..:...:.|.::|||||||:|..|.:.|..|..|.:|.|.||||||:.|..|
Human   609 EKPYKCSKCGKFFRYRCTLSRHQKVHTGERPYECSECGKFFRDSYKLIIHQRVHTGEKPYECSNC 673

  Fly   355 EDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVEL----QSH-------VEHCAKCPVD 408
            ...:.: :...:|:|  |:...:||:.|..|.:.|:.|..|    |||       :..|.|   |
Human   674 GKFLRY-RSTFIKHH--KVCTGEKPHECSKCRELFRTKSSLIIHQQSHTGESPFKLRECGK---D 732

  Fly   409 GDK---------PSGNQS-EDAQILSVLRFNMAVVLKKI 437
            .:|         .:|.:| |..:...|.::|.:::..:|
Human   733 FNKCNTGQRQKTHTGERSYECGESSKVFKYNSSLIKHQI 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/172 (31%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	12/26 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/22 (32%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	8/32 (25%)
		COG5048	<192..369	CDD:227381	58/235 (25%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/60 (12%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	4/19 (21%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	5/22 (23%)
		C2H2 Zn finger	382..399	CDD:275368	8/27 (30%)
ZNF749	NP_001018855.2	KRAB	8..62	CDD:214630
		KRAB	10..47	CDD:279668
		C2H2 Zn finger	202..218	CDD:275368
		C2H2 Zn finger	226..246	CDD:275368
		C2H2 Zn finger	258..274	CDD:275368
		COG5048	295..689	CDD:227381	97/342 (28%)
		C2H2 Zn finger	300..320	CDD:275368
		C2H2 Zn finger	328..348	CDD:275368
		C2H2 Zn finger	356..376	CDD:275368	8/19 (42%)
		zf-H2C2_2	371..393	CDD:290200	10/21 (48%)
		C2H2 Zn finger	384..404	CDD:275368	7/22 (32%)
		C2H2 Zn finger	412..432	CDD:275368	8/19 (42%)
		zf-H2C2_2	424..449	CDD:290200	10/24 (42%)
		C2H2 Zn finger	440..460	CDD:275368	8/19 (42%)
		C2H2 Zn finger	485..505	CDD:275368	7/19 (37%)
		C2H2 Zn finger	513..533	CDD:275368	4/19 (21%)
		C2H2 Zn finger	558..578	CDD:275368	4/19 (21%)
		C2H2 Zn finger	586..606	CDD:275368	5/19 (26%)
		zf-H2C2_2	599..623	CDD:290200	8/23 (35%)
		C2H2 Zn finger	614..634	CDD:275368	4/19 (21%)
		zf-H2C2_2	627..649	CDD:290200	10/21 (48%)
		C2H2 Zn finger	642..662	CDD:275368	7/19 (37%)
		C2H2 Zn finger	670..689	CDD:275368	4/21 (19%)
		C2H2 Zn finger	698..718	CDD:275368	6/19 (32%)
		C2H2 Zn finger	727..745	CDD:275368	4/20 (20%)
		C2H2 Zn finger	753..773	CDD:275368	3/19 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910