DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF888

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_016882287.1	Gene:	ZNF888 / 388559	HGNCID:	38695	Length:	830	Species:	Homo sapiens

Alignment Length:	314	Identity:	116/314 - (36%)
Similarity:	169/314 - (53%)	Gaps:	15/314 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCS 153
            :.|.:.|::|.|.||..:.|..|..||:.|:|:||.:|||.:.|..||..| ...|...|.:.|.
Human   518 REKPYKCNECGKTFGENSALLVHKTIHTGEKPYKCNECGKVFNQQSNLARH-HRLHTGEKPYKCK 581

  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218
            :|.|.|:.|..|..|.|:|:|||||.|.:|||.|.|...|.||.|.|  |..:.:.|.:|..:|.
Human   582 ECDKVFSRKSHLERHRRIHTGEKPYKCKVCDKAFRRDSHLAQHTVIH--TGEKPYKCNECGKTFV 644

  Fly   219 TNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKL----TQFECEICHKMIEPDED 279
            .|::|.:|...|.....::|:.|...|.::.:|     ..||:|    ..::|..|.|:......
Human   645 QNSSLVMHKVIHTGEKRYKCNECGKSFNHKSSL-----AYHHRLHTGEKPYKCNECGKVFRTQSQ 704

  Fly   280 LATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHT 344
            ||.|.:.||..|.:.||.|:..|..||...:|.|:||||:||:||:|.:.|...|.|..|.|.||
Human   705 LACHHRLHTGEKPYKCEECDKVFNIKSHLEIHRRVHTGEKPYKCRVCDKAFGRDSYLAQHQRVHT 769

  Fly   345 GEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            ||||::|::|:.  ||...:||..| .:||..:||:.|..|...|:.:..|..|
Human   770 GEKPYKCKVCDK--AFKCYSHLAQH-TRIHTGEKPFKCSECGKAFRAQSTLIHH 820

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	59/157 (38%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	10/19 (53%)
		COG5048	<192..369	CDD:227381	63/180 (35%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	4/21 (19%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
ZNF888	XP_016882287.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000