DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF728

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001254645.1	Gene:	ZNF728 / 388523	HGNCID:	32463	Length:	622	Species:	Homo sapiens

Alignment Length:	358	Identity:	116/358 - (32%)
Similarity:	174/358 - (48%)	Gaps:	17/358 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 RKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKS---ARKGEPVKRKHHVCSQCSKEFGGK 105
            |.|||       ::.:....||:..|.::..:...|.|   |.|......|.:.|.:|.|.|...
Human   267 RSSSL-------IEHKRSHAGEKPYKCEECGKAFSKASTLTAHKTIHAGEKPYKCEECGKAFNRS 324

  Fly   106 TDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMR 170
            ::|..|..||:.|:|.||::|||::.....|..| ...|...|.:.|.:|.|:|:....|..|.|
Human   325 SNLMEHKRIHTGEKPCKCEECGKAFGNFSTLTKH-KVIHTGEKPYKCEECGKAFSWPSSLTEHKR 388

  Fly   171 LHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGME 235
            :|:|:|||.|:.|.|.|.....|.:|.:.|  |..:.:.|.:|..:|:|.::|..|...|.....
Human   389 IHAGDKPYKCEECGKTFKWSSTLTKHKIIH--TGEKPYKCEECGKAFTTFSSLTKHKVIHTGEKH 451

  Fly   236 HRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNT 300
            ::|..|...|:...:|..| ...|.....::||.|.|..:...:|..|.:.||..|.:.||.|..
Human   452 YKCEECGKVFSWSSSLTTH-KAIHAGEKLYKCEECGKAFKWSSNLMEHKRIHTGEKPYKCEECGK 515

  Fly   301 YFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAH 365
            .|::.:....|..:||||:.|:|..|.:.|..||.|..|.|.||||||::|:.|..  |||.::.
Human   516 AFSKVANLTKHKVIHTGEKQYKCEECGKAFIWSSRLSEHKRIHTGEKPYKCEECGK--AFSWVSV 578

  Fly   366 LKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH 398
            |..| ||||..:|.|.||.|...|.....|.:|
Human   579 LNKH-KKIHAGKKFYKCEECGKDFNQSSHLTTH 610

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/158 (32%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF728	NP_001254645.1	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	146..167	CDD:275370
		C2H2 Zn finger	175..195	CDD:275368
		COG5048	186..583	CDD:227381	104/329 (32%)
		C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	258..278	CDD:275368	4/17 (24%)
		C2H2 Zn finger	286..306	CDD:275368	4/19 (21%)
		C2H2 Zn finger	314..334	CDD:275368	6/19 (32%)
		zf-H2C2_2	326..349	CDD:290200	11/22 (50%)
		C2H2 Zn finger	342..362	CDD:275368	6/20 (30%)
		zf-H2C2_2	355..378	CDD:290200	7/23 (30%)
		C2H2 Zn finger	370..390	CDD:275368	7/19 (37%)
		zf-H2C2_2	382..406	CDD:290200	11/23 (48%)
		C2H2 Zn finger	398..418	CDD:275368	6/19 (32%)
		zf-H2C2_2	411..435	CDD:290200	7/25 (28%)
		C2H2 Zn finger	426..446	CDD:275368	6/19 (32%)
		C2H2 Zn finger	454..474	CDD:275368	5/20 (25%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		zf-H2C2_2	494..518	CDD:290200	8/23 (35%)
		C2H2 Zn finger	510..530	CDD:275368	5/19 (26%)
		zf-H2C2_2	522..545	CDD:290200	8/22 (36%)
		C2H2 Zn finger	538..558	CDD:275368	8/19 (42%)
		zf-H2C2_2	551..574	CDD:290200	12/24 (50%)
		C2H2 Zn finger	566..586	CDD:275368	9/22 (41%)
		C2H2 Zn finger	594..614	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910