DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Gm5141

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001242994.1	Gene:	Gm5141 / 380850	MGIID:	3779466	Length:	581	Species:	Mus musculus

Alignment Length:	358	Identity:	129/358 - (36%)
Similarity:	197/358 - (55%)	Gaps:	19/358 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    65 EQDSKDDDYVQPQLKKSARKGE-PVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGK 128
            |.|.....:...|..:....|| |.|     |::|.|.|..|..||:|:.||:.|:|:||..|.|
Mouse   221 ECDKAFSQFGNLQNHRRTHTGEKPFK-----CNECDKAFSEKGSLQKHISIHTGEKPYKCNQCDK 280

  Fly   129 SYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQL 193
            ::....:|..|| ..|...|.:.|:||.|:|:.|..|:.|:|:|||||||.|:||||.|:|...|
Mouse   281 AFSHKQSLLIHI-RIHTGEKPYKCNQCDKAFSHKHILKNHIRIHSGEKPYKCNLCDKVFSRHFHL 344

  Fly   194 QQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQE 258
            |.|:.:|  |..:.:.|.:|..:||.:..|:.|.:.|......:|:.|:..|:.:.:|::|| :.
Mouse   345 QNHIRTH--TGEKPYRCNQCDKAFSHHKTLQTHRKTHTGEKPFKCNECDKAFSEKGSLQSHI-RT 406

  Fly   259 HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQC 323
            |.....::|..|.|.....::|..|::.||..|.:.|..|:..|:.|....:|:|:||||:||:|
Mouse   407 HTGEKPYKCNQCDKAFSHKQNLQIHIRIHTGEKPYKCNQCDKAFSYKQNLQIHIRIHTGEKPYKC 471

  Fly   324 RICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDF 388
            ..|.:.|.|...|:.|.|.||.:|||:|.|| |:| ||:..||:||: :.|.::|||.|..|...
Mouse   472 NQCDKAFLHQGNLQTHRRTHTRDKPFQCNLC-DKV-FSRHFHLQNHI-RTHTREKPYKCNECGKG 533

  Fly   389 FKIKVELQSHVEHCAKCPVDGDKP-SGNQSEDA 420
            |.....||:|     :....|:|| ..||.:.|
Mouse   534 FSQHSSLQTH-----RRTHTGEKPFKCNQCDKA 561

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	60/158 (38%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	16/23 (70%)
		C2H2 Zn finger	180..200	CDD:275368	10/19 (53%)
		COG5048	<192..369	CDD:227381	60/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	11/22 (50%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Gm5141	NP_001242994.1	KRAB	4..>45	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	136..155	CDD:275368
		zf-H2C2_2	148..171	CDD:290200
		C2H2 Zn finger	163..183	CDD:275368
		zf-H2C2_2	175..200	CDD:290200
		COG5048	187..566	CDD:227381	129/358 (36%)
		C2H2 Zn finger	191..211	CDD:275368
		zf-H2C2_2	203..228	CDD:290200	2/6 (33%)
		C2H2 Zn finger	219..239	CDD:275368	3/17 (18%)
		zf-H2C2_2	231..255	CDD:290200	8/28 (29%)
		C2H2 Zn finger	247..267	CDD:275368	8/19 (42%)
		zf-H2C2_2	259..284	CDD:290200	11/24 (46%)
		C2H2 Zn finger	275..295	CDD:275368	6/20 (30%)
		zf-H2C2_2	287..312	CDD:290200	10/25 (40%)
		C2H2 Zn finger	303..323	CDD:275368	9/19 (47%)
		zf-H2C2_2	316..340	CDD:290200	16/23 (70%)
		C2H2 Zn finger	331..351	CDD:275368	10/19 (53%)
		zf-H2C2_2	343..368	CDD:290200	8/26 (31%)
		C2H2 Zn finger	359..379	CDD:275368	6/19 (32%)
		zf-H2C2_2	372..395	CDD:290200	5/22 (23%)
		C2H2 Zn finger	387..407	CDD:275368	6/20 (30%)
		zf-H2C2_2	399..424	CDD:290200	7/25 (28%)
		C2H2 Zn finger	415..435	CDD:275368	5/19 (26%)
		zf-H2C2_2	427..452	CDD:290200	8/24 (33%)
		C2H2 Zn finger	443..463	CDD:275368	6/19 (32%)
		zf-H2C2_2	455..480	CDD:290200	11/24 (46%)
		C2H2 Zn finger	471..491	CDD:275368	7/19 (37%)
		C2H2 Zn finger	499..519	CDD:275368	11/22 (50%)
		zf-H2C2_2	511..536	CDD:290200	11/25 (44%)
		C2H2 Zn finger	527..547	CDD:275368	6/24 (25%)
		zf-H2C2_2	539..564	CDD:290200	9/28 (32%)
		C2H2 Zn finger	555..575	CDD:275368	3/7 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910