DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF680

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_848653.2	Gene:	ZNF680 / 340252	HGNCID:	26897	Length:	530	Species:	Homo sapiens

Alignment Length:	370	Identity:	118/370 - (31%)
Similarity:	163/370 - (44%)	Gaps:	53/370 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 KRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCS 153
            :...:.|.:|.|.....::|.:|..||..|:|:||::|||::.|:..|..| ...|...|.|.|.
Human   206 RENSYKCEECGKVLNWFSELIKHKGIHMGEKPYKCEECGKAFNQSSTLIKH-KKIHIEEKPFKCE 269

  Fly   154 QCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFS 218
            :|.|:|:|...|..|..:|:|:|||.||.|.|.|.....|..|...|  |..:.|.|.:|...|:
Human   270 ECGKAFSLFSILSKHKIIHTGDKPYKCDECHKAFNWFATLTNHKRIH--TGEKPFKCEECGKDFN 332

  Fly   219 TNANLRVHMERHEQGMEHRCSICE---NQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDL 280
            ..:||..|.:.|.....::|..|.   |||||   |..| .:.|.....::||.|.|......:|
Human   333 QFSNLTKHKKIHTGEKPYKCEECGKAFNQFAN---LTRH-KKIHTGEKSYKCEECGKAFIQSSNL 393

  Fly   281 ATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTG 345
            ..||:.||..|.:.||.|...|...|....|.|:||.|..|:|..|.:.|...|.|..|...|||
Human   394 TEHMRIHTGEKPYKCEECGKAFNGCSSLTRHKRIHTRENTYKCEECGKGFTLFSTLTNHKVIHTG 458

  Fly   346 EKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGD 410
            ||.::|..|.:  .|:..|.|.|| |:||.::|||.||.|...|.....|..|
Human   459 EKSYKCDECGN--VFNWPATLANH-KRIHAREKPYKCEECGKAFNRSSHLTRH------------ 508

  Fly   411 KPSGNQSEDAQILSVLRFNMAVVLKKISSAQKLRQLGYEKRLIDN 455
                                    |||.:.:||    |:....||
Human   509 ------------------------KKIHTGEKL----YKPEKCDN 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/160 (34%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	59/179 (33%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	9/24 (38%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF680	NP_848653.2	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		COG5048	152..513	CDD:227381	113/352 (32%)
		zf-C2H2	182..204	CDD:278523
		C2H2 Zn finger	184..204	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368	5/19 (26%)
		zf-H2C2_2	224..249	CDD:290200	11/24 (46%)
		C2H2 Zn finger	240..260	CDD:275368	7/20 (35%)
		zf-H2C2_2	253..276	CDD:290200	8/23 (35%)
		C2H2 Zn finger	268..288	CDD:275368	7/19 (37%)
		zf-H2C2_2	281..304	CDD:290200	11/22 (50%)
		C2H2 Zn finger	296..316	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..333	CDD:290200	8/25 (32%)
		C2H2 Zn finger	324..344	CDD:275368	6/19 (32%)
		zf-H2C2_2	336..361	CDD:290200	6/24 (25%)
		C2H2 Zn finger	352..372	CDD:275368	9/23 (39%)
		zf-H2C2_2	364..389	CDD:290200	8/28 (29%)
		C2H2 Zn finger	380..400	CDD:275368	7/19 (37%)
		zf-H2C2_2	392..416	CDD:290200	9/23 (39%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	6/19 (32%)
		C2H2 Zn finger	464..484	CDD:275368	8/22 (36%)
		zf-H2C2_2	477..501	CDD:290200	13/24 (54%)
		zf-C2H2	490..512	CDD:278523	9/57 (16%)
		C2H2 Zn finger	492..512	CDD:275368	8/55 (15%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000