DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp780b

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001074490.1	Gene:	Zfp780b / 338354	MGIID:	2444764	Length:	806	Species:	Mus musculus

Alignment Length:	537	Identity:	136/537 - (25%)
Similarity:	202/537 - (37%)	Gaps:	158/537 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RSVSKEDAVSLL----------------------TD---SGISLSSP------------------ 27
            |.:||.|.:.||                      ||   ..||..:|
Mouse    56 RCISKPDLIVLLEQEKEPWMAVKEETDRPSPDLETDYDAENISPENPINNKKFLKQSIKQLITFD 120

  Fly    28 PAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKH 92
            |....:|.||..      |:...|:|.     :.|.|:|.:..:.......:..|...|    |.
Mouse   121 PKDSSTSIGPNY------STFHGLQDC-----QSDAGQQITNKEGVPPHTCQTLAHNTE----KP 170

  Fly    93 HVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPK 157
            :.|.:|.|.||.::.|.:|..||:.|:|::|::|||::|....|..| ..:|...|.|.|::|.|
Mouse   171 YECKECGKCFGCRSTLTQHQSIHTGEKPYECEECGKAFRLPQQLTRH-QKSHSGEKPFECNECGK 234

  Fly   158 SFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNAN 222
            :|.|.:.|:.|..:|:||||:.|..|.|.|.|...|..|.:.|  ..::.:.|::|..:|...:|
Mouse   235 AFHLPDLLKYHKTIHTGEKPFECRECGKSFNRVSNLVAHRIIH--ADVKPYKCSECGKAFKRRSN 297

  Fly   223 LRVHMERHEQGMEHRCSICENQF------------------------------------------ 245
            |..|.:.|......:|..|...|
Mouse   298 LVQHQKTHSDERPFQCKDCGKGFIVLAQLTRHQNIHTGEKSFECHECGKAFRLPQQLTRHQKSHS 362

  Fly   246 ------ANELALRAHINQ--EHHKLTQ-----FECEICHKMIEPDEDLATHMQRHTAVKTHVCEV 297
                  .||.....|:..  ::||...     |||..|.|......:|..|...|..||.|.|..
Mouse   363 GEKPFKCNECGKAFHLPDLLKYHKTIHTSTKPFECRECGKSFHRISNLVEHRLIHADVKPHKCNE 427

  Fly   298 CNTYFTQKSQYNVHMRMHTGERPYQCRIC------------HQT----------------FAHSS 334
            |...|.:......|.::|:||||:||:.|            |||                |..::
Mouse   428 CGKAFKRSKSLMQHQKIHSGERPFQCQECGKAFIVLTHLTRHQTIHTGEKSFECNECGKKFRTAT 492

  Fly   335 VLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH- 398
            .|.:|...|||||||.|.:|..  ||....:|..| :|||.::||:.|:.|...|:.|.:|..|
Mouse   493 HLVMHQTIHTGEKPFECNVCGK--AFRLQVYLSEH-QKIHIEEKPFKCKLCGSAFRRKYQLNEHY 554

  Fly   399 ----------VEHCAKC 405
                      .:.|.||
Mouse   555 TIHTDEKPYQCKECGKC 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/206 (25%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	59/259 (23%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/71 (8%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	4/19 (21%)
		zf-H2C2_2	309..332	CDD:290200	13/50 (26%)
		C2H2 Zn finger	323..343	CDD:275368	8/47 (17%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	6/27 (22%)
Zfp780b	NP_001074490.1	KRAB	14..75	CDD:214630	6/18 (33%)
		C2H2 Zn finger	173..193	CDD:275368	7/19 (37%)
		COG5048	197..605	CDD:227381	102/381 (27%)
		C2H2 Zn finger	201..221	CDD:275368	7/20 (35%)
		C2H2 Zn finger	229..249	CDD:275368	7/19 (37%)
		C2H2 Zn finger	257..277	CDD:275368	7/19 (37%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		C2H2 Zn finger	313..333	CDD:275368	3/19 (16%)
		C2H2 Zn finger	341..361	CDD:275368	0/19 (0%)
		C2H2 Zn finger	369..389	CDD:275368	5/19 (26%)
		C2H2 Zn finger	397..417	CDD:275368	5/19 (26%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		C2H2 Zn finger	453..473	CDD:275368	5/19 (26%)
		C2H2 Zn finger	481..501	CDD:275368	3/19 (16%)
		C2H2 Zn finger	509..529	CDD:275368	7/22 (32%)
		C2H2 Zn finger	537..557	CDD:275368	6/19 (32%)
		C2H2 Zn finger	565..585	CDD:275368	3/7 (43%)
		C2H2 Zn finger	593..613	CDD:275368
		C2H2 Zn finger	621..641	CDD:275368
		C2H2 Zn finger	649..669	CDD:275368
		C2H2 Zn finger	677..697	CDD:275368
		C2H2 Zn finger	705..725	CDD:275368
		C2H2 Zn finger	733..753	CDD:275368
		C2H2 Zn finger	761..781	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000