DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF852

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001274278.1	Gene:	ZNF852 / 285346	HGNCID:	27713	Length:	530	Species:	Homo sapiens

Alignment Length:	457	Identity:	135/457 - (29%)
Similarity:	205/457 - (44%)	Gaps:	86/457 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 DSGISLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKD--DDYVQ----PQ 77
            |:...|...|:..|.|        |.:|....:    :||::    ::.:||  ::|.:    |.
Human    93 DTFKELEGQPSNEEGS--------RLESDFLEI----IDEDK----KKSTKDRYEEYKEVEEHPP 141

  Fly    78 LKKSARKGEPVKR--KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHI 140
            |..|..:.|.|.:  |.:.|.:|.|.|...:.|..|..||:.|:|::|.:|||::||...|..|:
Human   142 LSSSPVEHEGVLKGQKSYRCDECGKAFYWSSHLIGHRRIHTGEKPYECNECGKTFRQTSQLIVHL 206

  Fly   141 TTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSH----- 200
            .| |...|.:.||:|.|::.....|..|.|||:|||||.|:.|.|.|.:..:|..|..:|
Human   207 RT-HTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFNQSSKLFDHQRTHTGEKP 270

  Fly   201 ------------------HK---TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQ 244
                              |:   |..:.:.|.:|..:|.:|.||..|...|.....::|:.|...
Human   271 YECKECGAAFSRSKNLVRHQFLHTGKKPYKCNECGRAFCSNRNLIDHQRTHTGEKPYKCNECGKA 335

  Fly   245 FANELALRAH------------------INQ-----EHHKL----TQFECEICHKMIEPDEDLAT 282
            |:....|..|                  .||     ||.::    ..|:|..|.|.....:.|..
Human   336 FSRSKCLIRHQSLHTGEKPYKCSECGKAFNQISQLVEHERIHTGEKPFKCSECGKAFGLSKCLIR 400

  Fly   283 HMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEK 347
            |.:.||:.|.:.|..|...|.|.|...:|.|:||||:||:|..|.:.|:::|.|.:|.|.|||||
Human   401 HQRLHTSEKPYKCNECGKSFNQNSYLIIHQRIHTGEKPYECNECGKVFSYNSSLMVHQRTHTGEK 465

  Fly   348 PFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVEHCAKCPVDGDKP 412
            |::|..|..  |||..:.|..| :::|..:|||.|..|...|..:.....|....|     |:||
Human   466 PYKCNSCGK--AFSDSSQLTVH-QRVHTGEKPYECIECGKAFSQRSTFNHHQRTHA-----GEKP 522

  Fly   413 SG 414
            ||
Human   523 SG 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	57/186 (31%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	63/229 (28%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	8/44 (18%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	3/16 (19%)
ZNF852	NP_001274278.1	KRAB_A-box	8..47	CDD:143639
		COG5048	156..514	CDD:227381	111/361 (31%)
		C2H2 Zn finger	161..181	CDD:275368	6/19 (32%)
		zf-H2C2_2	177..198	CDD:290200	9/20 (45%)
		C2H2 Zn finger	189..209	CDD:275368	9/20 (45%)
		zf-H2C2_2	202..226	CDD:290200	9/24 (38%)
		C2H2 Zn finger	217..237	CDD:275368	7/19 (37%)
		C2H2 Zn finger	245..265	CDD:275368	6/19 (32%)
		zf-H2C2_2	261..282	CDD:290200	2/20 (10%)
		C2H2 Zn finger	273..293	CDD:275368	1/19 (5%)
		zf-C2H2	299..321	CDD:278523	7/21 (33%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	313..338	CDD:290200	7/24 (29%)
		C2H2 Zn finger	329..349	CDD:275368	5/19 (26%)
		zf-H2C2_2	342..366	CDD:290200	2/23 (9%)
		C2H2 Zn finger	357..377	CDD:275368	4/19 (21%)
		zf-H2C2_2	370..392	CDD:290200	6/21 (29%)
		C2H2 Zn finger	385..405	CDD:275368	5/19 (26%)
		zf-H2C2_2	398..422	CDD:290200	8/23 (35%)
		C2H2 Zn finger	413..433	CDD:275368	7/19 (37%)
		zf-H2C2_2	425..450	CDD:290200	11/24 (46%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..477	CDD:290200	12/25 (48%)
		C2H2 Zn finger	469..489	CDD:275368	7/22 (32%)
		zf-H2C2_2	482..506	CDD:290200	9/24 (38%)
		C2H2 Zn finger	497..517	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910