DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF875

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_016882161.1	Gene:	ZNF875 / 284459	HGNCID:	4928	Length:	704	Species:	Homo sapiens

Alignment Length:	471	Identity:	131/471 - (27%)
Similarity:	192/471 - (40%)	Gaps:	107/471 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 SLSSPPAARESSPGPTLAIKRRKS--SLASLRDACVDEEEDD--------GGEQDSKDDDYVQPQ 77
            :|||||  .|..|..:   |...:  .:.|..:...|.||.|        .|..:.|.:::....
Human   240 ALSSPP--EEQQPAQS---KEDNTVVDIGSSPERRADLEETDKVLHGLEVSGFGEIKYEEFGPGF 299

  Fly    78 LKKS-------ARKGEP-----------------VKR-------KHHVCSQCSKEFGGKTDLQRH 111
            :|:|       .:.||.                 :|.       |.:||.:|.:.|..|::|..|
Human   300 IKESNLLSLQKTQTGETPYMYTEWGDSFGSMSVLIKNPRTHSGGKPYVCRECGRGFTWKSNLITH 364

  Fly   112 MLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEK 176
            ...||.|:|:.|||||:.:....||..|..| |...|.:||.:|.:||:||..|..|.|.|:|||
Human   365 QRTHSGEKPYVCKDCGRGFTWKSNLFTHQRT-HSGLKPYVCKECGQSFSLKSNLITHQRAHTGEK 428

  Fly   177 PYPCDLCDKKFARGGQLQQHMVSHHKT--SIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCS 239
            ||.|..|    .||.:...|:|.|.:|  ..:.:.|.:|...||..::|..|:..|.....:.|:
Human   429 PYVCREC----GRGFRQHSHLVRHKRTHSGEKPYICRECEQGFSQKSHLIRHLRTHTGEKPYVCT 489

  Fly   240 ICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQ 304
            .|...|:.:..|:.| .:.|..:..:.|..|.:......:|..|.:.||..|..||..|...||:
Human   490 ECGRHFSWKSNLKTH-QRTHSGVKPYVCLECGQCFSLKSNLNKHQRSHTGEKPFVCTECGRGFTR 553

  Fly   305 KSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC--------------- 354
            ||..:.|.|.|:||:|:.|..|.:.|...|.|..|.|.|:|||||.|:.|
Human   554 KSTLSTHQRTHSGEKPFVCAECGRGFNDKSTLISHQRTHSGEKPFMCRECGRRFRQKPNLFRHKR 618

  Fly   355 -------------------------------------EDEVAFSQLAHLKNHMKKIHKQQKPYMC 382
                                                 |....||:.:||..| ::.|..:|||:|
Human   619 AHSGAFVCRECGQGFCAKLTLIKHQRAHAGGKPHVCRECGQGFSRQSHLIRH-QRTHSGEKPYIC 682

  Fly   383 EGCHDFFKIKVELQSH 398
            ..|...|..|..|..|
Human   683 RKCGRGFSRKSNLIRH 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/167 (35%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	57/230 (25%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	9/22 (41%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/74 (11%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF875	XP_016882161.1	KRAB	77..136	CDD:214630
		C2H2 Zn finger	324..340	CDD:275368	1/15 (7%)
		COG5048	344..703	CDD:227381	111/362 (31%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..396	CDD:275368	9/20 (45%)
		C2H2 Zn finger	404..424	CDD:275368	9/19 (47%)
		C2H2 Zn finger	432..452	CDD:275368	7/23 (30%)
		C2H2 Zn finger	460..480	CDD:275368	6/19 (32%)
		C2H2 Zn finger	488..508	CDD:275368	5/20 (25%)
		C2H2 Zn finger	516..536	CDD:275368	4/19 (21%)
		C2H2 Zn finger	544..564	CDD:275368	8/19 (42%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	2/19 (11%)
		C2H2 Zn finger	626..646	CDD:275368	0/19 (0%)
		C2H2 Zn finger	654..674	CDD:275368	6/20 (30%)
		C2H2 Zn finger	682..702	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910