DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF493

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001070146.1	Gene:	ZNF493 / 284443	HGNCID:	23708	Length:	774	Species:	Homo sapiens

Alignment Length:	337	Identity:	113/337 - (33%)
Similarity:	171/337 - (50%)	Gaps:	25/337 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 KSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITT-- 142
            |....||    |.:.|.:|.|.|...:.|.:|.:||::|:.|:|::|||:|:::    :|:||
Human   368 KRIHTGE----KPYKCEECGKAFSIFSTLTKHKIIHTEEKSHRCEECGKAYKES----SHLTTHK 424

  Fly   143 -AHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
             .|...|.:.|.:|.|:|::...|..|..:|:.||||.|:.|.|.|.|...|.:|.:.|  |..:
Human   425 RIHTGEKPYKCEECGKTFSVFSILTKHKIIHTEEKPYKCEECGKAFKRSSTLTKHRIIH--TEEK 487

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICH 271
            .:.|.:|..:|:.::.|.:|...|.....::|..|...|.....|..| ...|.....::||.|.
Human   488 PYKCEECGKAFNQSSTLSIHKIIHTGEKPYKCEECGKAFKRSSTLTIH-KMIHTGEKPYKCEECG 551

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            |.......|.||.:.||..|.:.|:.|...|:..|....|..:||.::||:|..|.:.|..||:|
Human   552 KAFNRSSHLTTHKRIHTGHKPYKCKECGKSFSVFSTLTKHKIIHTDKKPYKCEECGKAFNRSSIL 616

  Fly   337 KLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-VE 400
            .:|.:.||||||::|:.|..  ||.:.:||..| |:||..||||.||.|...|.|...|..| :.
Human   617 SIHKKIHTGEKPYKCEECGK--AFKRSSHLAGH-KQIHSVQKPYKCEECGKAFSIFSTLTKHKII 678

  Fly   401 H-------CAKC 405
            |       |.||
Human   679 HTEEKPYKCEKC 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	50/161 (31%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/23 (35%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	54/176 (31%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	7/19 (37%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	8/22 (36%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	7/17 (41%)
ZNF493	NP_001070146.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	184..204	CDD:275368
		C2H2 Zn finger	212..232	CDD:275368
		C2H2 Zn finger	241..259	CDD:275368
		COG5048	262..667	CDD:227381	105/312 (34%)
		C2H2 Zn finger	267..287	CDD:275368
		C2H2 Zn finger	295..315	CDD:275368
		C2H2 Zn finger	351..371	CDD:275368	1/2 (50%)
		zf-H2C2_2	363..387	CDD:290200	7/22 (32%)
		C2H2 Zn finger	379..399	CDD:275368	6/19 (32%)
		C2H2 Zn finger	407..427	CDD:275368	8/23 (35%)
		zf-H2C2_2	419..443	CDD:290200	8/23 (35%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		zf-H2C2_2	448..472	CDD:290200	11/23 (48%)
		C2H2 Zn finger	463..483	CDD:275368	7/19 (37%)
		C2H2 Zn finger	491..511	CDD:275368	5/19 (26%)
		zf-H2C2_2	504..528	CDD:290200	6/23 (26%)
		C2H2 Zn finger	519..539	CDD:275368	5/20 (25%)
		zf-H2C2_2	532..556	CDD:290200	7/24 (29%)
		C2H2 Zn finger	547..567	CDD:275368	7/19 (37%)
		zf-H2C2_2	559..583	CDD:290200	8/23 (35%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	603..623	CDD:275368	7/19 (37%)
		zf-H2C2_2	616..640	CDD:290200	12/25 (48%)
		C2H2 Zn finger	631..651	CDD:275368	8/22 (36%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)
		C2H2 Zn finger	687..707	CDD:275368	3/4 (75%)
		C2H2 Zn finger	715..735	CDD:275368
		C2H2 Zn finger	743..763	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000