DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF841

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001356754.1	Gene:	ZNF841 / 284371	HGNCID:	27611	Length:	925	Species:	Homo sapiens

Alignment Length:	343	Identity:	114/343 - (33%)
Similarity:	165/343 - (48%)	Gaps:	32/343 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.::|::|.|.|...:.|..|..||:.|:|:||..|||.:.|:.:|..| .|.|...|.:.|::|
Human   344 KPYICNECGKSFSKSSHLAVHQRIHTGEKPYKCNRCGKCFSQSSSLATH-QTVHTGDKPYKCNEC 407

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSH-------------------- 200
            .|:|.....|..|..:|:|:|||.||:|.|.|.:..||.:|.:.|
Human   408 GKTFKRNSSLTAHHIIHAGKKPYTCDVCGKVFYQNSQLVRHQIIHTGETPYKCNECGKVFFQRSR 472

  Fly   201 ---HK---TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEH 259
               |:   |..:.:.|.:|...||.:::|.||...|.....::|:.|...|.....|..| .:.|
Human   473 LAGHRRIHTGEKPYKCNECGKVFSQHSHLAVHQRVHTGEKPYKCNECGKAFNWGSLLTVH-QRIH 536

  Fly   260 HKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCR 324
            .....::|.:|.|:......|:.||:.||..|...|..|...||..|....|.||||||:||:|.
Human   537 TGEKPYKCNVCGKVFNYGGYLSVHMRCHTGEKPLHCNKCGMVFTYYSCLARHQRMHTGEKPYKCN 601

  Fly   325 ICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFF 389
            :|.:.|..|..|.:|.|.|||||||:|..|..  .||..:.|..| :|||..:|||.|..|...:
Human   602 VCGKVFIDSGNLSIHRRSHTGEKPFQCNECGK--VFSYYSCLARH-RKIHTGEKPYKCNDCGKAY 663

  Fly   390 KIKVELQSH-VEHCAKCP 406
            ..:..|..| |.|..:.|
Human   664 TQRSSLTKHLVIHTGENP 681

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/181 (30%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	62/202 (31%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	4/17 (24%)
ZNF841	NP_001356754.1	KRAB	8..69	CDD:214630
		COG5048	260..636	CDD:227381	97/295 (33%)
		C2H2 Zn finger	265..284	CDD:275368
		C2H2 Zn finger	292..312	CDD:275368
		C2H2 Zn finger	320..340	CDD:275368
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		C2H2 Zn finger	376..396	CDD:275368	8/20 (40%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..452	CDD:275368	8/19 (42%)
		C2H2 Zn finger	460..480	CDD:275368	1/19 (5%)
		COG5048	484..886	CDD:227381	70/202 (35%)
		C2H2 Zn finger	488..508	CDD:275368	7/19 (37%)
		C2H2 Zn finger	516..536	CDD:275368	5/20 (25%)
		C2H2 Zn finger	544..564	CDD:275368	6/19 (32%)
		C2H2 Zn finger	572..592	CDD:275368	7/19 (37%)
		C2H2 Zn finger	600..620	CDD:275368	7/19 (37%)
		C2H2 Zn finger	628..648	CDD:275368	7/22 (32%)
		C2H2 Zn finger	656..676	CDD:275368	5/19 (26%)
		C2H2 Zn finger	712..732	CDD:275368
		C2H2 Zn finger	740..760	CDD:275368
		C2H2 Zn finger	768..788	CDD:275368
		C2H2 Zn finger	796..816	CDD:275368
		C2H2 Zn finger	824..844	CDD:275368
		C2H2 Zn finger	852..872	CDD:275368
		C2H2 Zn finger	880..900	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000