DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF283

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_862828.1	Gene:	ZNF283 / 284349	HGNCID:	13077	Length:	679	Species:	Homo sapiens

Alignment Length:	418	Identity:	124/418 - (29%)
Similarity:	186/418 - (44%)	Gaps:	65/418 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNH--ITTA---------- 143
            |.:.|.:|.|.|...:.|.:|..||:.|:|::||:|||::.:..:|..|  |.|.
Human   261 KPYECKECGKTFSWGSSLVKHERIHTGEKPYECKECGKAFSRGYHLTQHQKIHTGVKSYKCKECG 325

  Fly   144 ---------------HEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQL 193
                           |...|.:.|.:|.|:|:...:|..|.::|:|:|||.|.:|.|.|..|.||
Human   326 KAFFWGSSLAKHEIIHTGEKPYKCKECGKAFSRGYQLTQHQKIHTGKKPYECKICGKAFCWGYQL 390

  Fly   194 QQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQE 258
            .:|.:.|  |..:.:.|.:|..:|:..::|..|...|.....:.|..|...|:...    |::|
Human   391 TRHQIFH--TGEKPYECKECGKAFNCGSSLIQHERIHTGEKPYECKECGKAFSRGY----HLSQ- 448

  Fly   259 HHKL----TQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGER 319
            |.|:    ..|||:.|.|.......|..|.:.||..|:|.|:.|...|....|...|...||||:
Human   449 HQKIHTGEKPFECKECGKAFSWGSSLVKHERVHTGEKSHECKECGKTFCSGYQLTRHQVFHTGEK 513

  Fly   320 PYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEG 384
            ||:|:.|.:.|...|.|..|.|.||||||:.|:.|..  |||:..||..| :|||..:||:.|:.
Human   514 PYECKECGKAFNCGSSLVQHERIHTGEKPYECKECGK--AFSRGYHLTQH-QKIHTGEKPFKCKE 575

  Fly   385 CHDFFKIKVELQSHV-----EHCAKCPVDGDKPSGNQSEDAQILSV-LRFNMAVVLKKISSAQKL 443
            |...|.....|..|.     |...:|     |..|........||| .||:         :.:||
Human   576 CGKAFSWGSSLVKHERVHTNEKSYEC-----KDCGKAFGSGYQLSVHQRFH---------TGEKL 626

  Fly   444 RQLGYEKRLIDNVIIASLKLAQRQSHDD 471
                |:::..........||...::|.:
Human   627 ----YQRKEFGKTFTCGSKLVHERTHSN 650

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	52/182 (29%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	9/47 (19%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	60/180 (33%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	9/22 (41%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF283	NP_862828.1	KRAB	72..113	CDD:307490
		C2H2 Zn finger	209..229	CDD:275368
		C2H2 Zn finger	237..257	CDD:275368
		COG5048	261..655	CDD:227381	124/418 (30%)
		C2H2 Zn finger	265..285	CDD:275368	6/19 (32%)
		C2H2 Zn finger	293..313	CDD:275368	7/19 (37%)
		C2H2 Zn finger	321..341	CDD:275368	0/19 (0%)
		C2H2 Zn finger	349..369	CDD:275368	6/19 (32%)
		C2H2 Zn finger	377..397	CDD:275368	8/19 (42%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	7/24 (29%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		C2H2 Zn finger	545..565	CDD:275368	9/22 (41%)
		C2H2 Zn finger	573..593	CDD:275368	5/19 (26%)
		C2H2 Zn finger	601..621	CDD:275368	7/24 (29%)
		C2H2 Zn finger	629..648	CDD:275368	2/18 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910