DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF780A

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_024307222.1	Gene:	ZNF780A / 284323	HGNCID:	27603	Length:	658	Species:	Homo sapiens

Alignment Length:	461	Identity:	130/461 - (28%)
Similarity:	193/461 - (41%)	Gaps:	73/461 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 RSVSKEDAVSLLTDSGISLSSPPAAR--ESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQDS 68
            |.|..|:...|::.:|.|:|.|....  |....|.:.:::..|.      ...|.|...|.|:.|
Human    48 RDVMLENYSHLISLAGSSISKPDVITLLEQEKEPWMVVRKETSR------RYPDLELKYGPEKVS 106

  Fly    69 KDDDYVQPQLKKSA---------------------RKGEPVK----------------------- 89
            .::|..:..|.|..                     |:.|.::
Human   107 PENDTSEVNLPKQVIKQISTTLGIEAFYFRNDSEYRQFEGLQGYQEGNINQKMISYEKLPTHTPH 171

  Fly    90 -------RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHR 147
                   .|.:.|.:|.|.|....:|.:|..||:.|:|.:||:|||::|..:....| ...|...
Human   172 ASLICNTHKPYECKECGKYFSRSANLIQHQSIHTGEKPFECKECGKAFRLHIQFTRH-QKFHTGE 235

  Fly   148 KQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTK 212
            |.|.|::|.|:|:|...|..|..:|:|||.:.|..|.|.|.|...|.||...|  :.::.:.|.:
Human   236 KPFECNECGKAFSLLTLLNRHKNIHTGEKLFECKECGKSFNRSSNLVQHQSIH--SGVKPYECKE 298

  Fly   213 CSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPD 277
            |...|:..|:|..|.:.|.......|..|...|.....|..|. |.|.....|||:.|.|.....
Human   299 CGKGFNRGAHLIQHQKIHSNEKPFVCKECGMAFRYHYQLIEHC-QIHTGEKPFECKECGKAFTLL 362

  Fly   278 EDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRK 342
            ..|..|.:.||..|...|..|...|:..:|.|.|..:||||:|::|:.|.::|..||.|..|...
Human   363 TKLVRHQKIHTGEKPFECRECGKAFSLLNQLNRHKNIHTGEKPFECKECGKSFNRSSNLVQHQSI 427

  Fly   343 HTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-HCAKCP 406
            |.|.||:.|:.|..  .|::.|||..| :|||..:||::|..|...|:...:|..|.. |
Human   428 HAGIKPYECKECGK--GFNRGAHLIQH-QKIHSNEKPFVCRECEMAFRYHCQLIEHSRIH----- 484

  Fly   407 VDGDKP 412
             .||||
Human   485 -TGDKP 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	51/188 (27%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	10/23 (43%)
		C2H2 Zn finger	180..200	CDD:275368	8/19 (42%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF780A	XP_024307222.1	KRAB	22..83	CDD:214630	10/34 (29%)
		C2H2 Zn finger	184..204	CDD:275368	6/19 (32%)
		zf-H2C2_2	196..220	CDD:316026	11/23 (48%)
		C2H2 Zn finger	212..232	CDD:275368	7/20 (35%)
		COG5048	236..612	CDD:227381	90/266 (34%)
		C2H2 Zn finger	240..260	CDD:275368	7/19 (37%)
		C2H2 Zn finger	268..288	CDD:275368	8/19 (42%)
		C2H2 Zn finger	296..316	CDD:275368	6/19 (32%)
		C2H2 Zn finger	324..344	CDD:275368	6/20 (30%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		C2H2 Zn finger	380..400	CDD:275368	6/19 (32%)
		C2H2 Zn finger	408..428	CDD:275368	7/19 (37%)
		C2H2 Zn finger	436..456	CDD:275368	8/22 (36%)
		C2H2 Zn finger	464..484	CDD:275368	5/19 (26%)
		C2H2 Zn finger	492..512	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		C2H2 Zn finger	548..568	CDD:275368
		C2H2 Zn finger	576..596	CDD:275368
		C2H2 Zn finger	604..624	CDD:275368
		C2H2 Zn finger	632..652	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910