DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF776

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_775903.3	Gene:	ZNF776 / 284309	HGNCID:	26765	Length:	518	Species:	Homo sapiens

Alignment Length:	334	Identity:	103/334 - (30%)
Similarity:	156/334 - (46%)	Gaps:	13/334 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 KDDDYVQPQLKKSARKGEPVK--RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYR 131
            ::|.:...:.....:.|.|::  :.|::|.:.:..|..|..|..|..:...|.|:.|.|.||...
Human   182 QEDIHTSGKSNFETKHGIPLQGGKTHYICGESTIPFSNKHSLVLHQRLLPREGPYVCSDSGKFTS 246

  Fly   132 QAVNLKNH--ITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQ 194
            ::.:..||  :.|.   ::.:.|.||.:||..|..|..|.|:|:||:||.|..|||.|:....|.
Human   247 KSNSFNNHQGVRTG---KRPYQCGQCDESFWYKAHLTEHQRVHTGERPYECGECDKSFSHKHSLV 308

  Fly   195 QHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEH 259
            .|...|  |..:.:.|.:|..|||...:|..|...|.....::|..|...|.::..|..| .:.|
Human   309 DHQRVH--TGERPYECDECGKSFSHKRSLVHHQRVHTGERPYQCGECGKSFNHKCNLIQH-QRVH 370

  Fly   260 HKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCR 324
            .....|||..|.|:...:..|..|.:.||..:.:.|:.|...|..||....|.|:|||||||:||
Human   371 TGERPFECTACGKLFRSNSHLKEHQRVHTGERPYECKECRKSFRYKSHLTEHQRVHTGERPYECR 435

  Fly   325 ICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFF 389
            .|.:.|.....|..|.:.|:||:|..|..|..  .|.|...|..| ::||..::|:.|..|...|
Human   436 ECGKCFHQKGSLIQHQQIHSGERPHECGECGK--CFHQKGSLIRH-QQIHSGERPHECGECGKCF 497

  Fly   390 KIKVELQSH 398
            :.|..|..|
Human   498 RQKGNLIKH 506

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	49/162 (30%)
		C2H2 Zn finger	95..115	CDD:275368	5/19 (26%)
		zf-H2C2_2	107..132	CDD:290200	8/24 (33%)
		C2H2 Zn finger	123..144	CDD:275368	7/22 (32%)
		C2H2 Zn finger	152..172	CDD:275368	9/19 (47%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	13/22 (59%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	6/22 (27%)
		C2H2 Zn finger	382..399	CDD:275368	6/17 (35%)
ZNF776	NP_775903.3	KRAB	14..>55	CDD:214630
		KRAB	14..53	CDD:279668
		C2H2 Zn finger	238..258	CDD:275368	6/19 (32%)
		C2H2 Zn finger	266..286	CDD:275368	9/19 (47%)
		zf-H2C2_2	278..303	CDD:290200	13/24 (54%)
		COG5048	<291..439	CDD:227381	51/150 (34%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	8/26 (31%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		zf-H2C2_2	334..359	CDD:290200	6/24 (25%)
		C2H2 Zn finger	350..370	CDD:275368	5/20 (25%)
		zf-H2C2_2	362..387	CDD:290200	8/25 (32%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		zf-H2C2_2	390..415	CDD:290200	7/24 (29%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		zf-H2C2_2	418..443	CDD:290200	13/24 (54%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	462..482	CDD:275368	6/22 (27%)
		C2H2 Zn finger	490..510	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910