DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZIK1

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001010879.2	Gene:	ZIK1 / 284307	HGNCID:	33104	Length:	487	Species:	Homo sapiens

Alignment Length:	351	Identity:	108/351 - (30%)
Similarity:	156/351 - (44%)	Gaps:	75/351 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 GGEQDSKDDDYVQPQLKKSAR-KGEPV-------KRKHHVCSQCSKEFGGKTDLQRHMLIHSDER 119
            |.:..|:...|...:..|::| |..||       .:|.:.||:|.|.|.||..|.:|..:|:.||
Human   201 GEDIRSQKSHYKSGECGKASRHKHTPVYHPRVYTGKKLYECSKCGKAFRGKYSLVQHQRVHTGER 265

  Fly   120 PHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCD 184
            |.:|.:|||.:.|         |:|                    |..|.|:|:||:||.|..|.
Human   266 PWECNECGKFFSQ---------TSH--------------------LNDHRRIHTGERPYECSECG 301

  Fly   185 KKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANEL 249
            |.|.:...|..|...|  |..:.:.|::|..|||..|.|..|...|.....::|..|.|.|:..
Human   302 KLFRQNSSLVDHQKIH--TGARPYECSQCGKSFSQKATLVKHQRVHTGERPYKCGECGNSFSQS- 363

  Fly   250 ALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRM 314
               |.:||                         |.:.||..|.:.|..|...|:||:....|.|:
Human   364 ---AILNQ-------------------------HRRIHTGAKPYECGQCGKSFSQKATLIKHQRV 400

  Fly   315 HTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKP 379
            |||||||:|..|.::|:.||:|..|.|.|||.:|:.|..|..  :|||.:.|..| :.:|..::|
Human   401 HTGERPYKCGDCGKSFSQSSILIQHRRIHTGARPYECGQCGK--SFSQKSGLIQH-QVVHTGERP 462

  Fly   380 YMCEGCHDFFKIKVELQSHVEHCAKC 405
            |.|..|.:.|.   :..|.:.| .||
Human   463 YECNKCGNSFS---QCSSLIHH-QKC 484

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	51/165 (31%)
		C2H2 Zn finger	95..115	CDD:275368	9/19 (47%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	6/20 (30%)
		C2H2 Zn finger	152..172	CDD:275368	3/19 (16%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	56/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	8/19 (42%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	1/19 (5%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZIK1	NP_001010879.2	KRAB	27..>68	CDD:214630
		KRAB	27..66	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..94
		C2H2 Zn finger	215..233	CDD:275368	5/17 (29%)
		C2H2 Zn finger	241..261	CDD:275368	9/19 (47%)
		zf-H2C2_2	253..278	CDD:290200	10/24 (42%)
		COG5048	<269..449	CDD:227381	74/241 (31%)
		C2H2 Zn finger	269..289	CDD:275368	10/48 (21%)
		zf-H2C2_2	281..306	CDD:290200	13/44 (30%)
		C2H2 Zn finger	297..317	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..334	CDD:290200	8/26 (31%)
		C2H2 Zn finger	325..345	CDD:275368	8/19 (42%)
		zf-H2C2_2	338..362	CDD:290200	7/23 (30%)
		C2H2 Zn finger	353..373	CDD:275368	8/48 (17%)
		zf-H2C2_2	366..390	CDD:290200	9/48 (19%)
		C2H2 Zn finger	381..401	CDD:275368	7/19 (37%)
		zf-H2C2_2	394..418	CDD:290200	12/23 (52%)
		C2H2 Zn finger	409..429	CDD:275368	8/19 (42%)
		zf-H2C2_2	422..446	CDD:290200	10/25 (40%)
		C2H2 Zn finger	437..457	CDD:275368	7/22 (32%)
		C2H2 Zn finger	465..485	CDD:275368	7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910