DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF311

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	XP_005249076.1	Gene:	ZNF311 / 282890	HGNCID:	13847	Length:	699	Species:	Homo sapiens

Alignment Length:	376	Identity:	124/376 - (32%)
Similarity:	180/376 - (47%)	Gaps:	44/376 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    95 CSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSF 159
            |:||.|.|..::.|.||...||.|:||:|:||||:::....|..| ...|...|.:.|:.|.|:|
Human   338 CTQCGKAFNSRSALCRHKKTHSGEKPHECRDCGKAFKTRNRLCMH-QLIHTGEKPYKCNCCGKAF 401

  Fly   160 ALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHM-----------------------VSHH 201
            ..|..|.:|.|:|:|||||.|:.|.|.|:....|.:|:                       :|.|
Human   402 QFKHSLTIHGRIHTGEKPYECEECGKAFSGSSDLTKHIRIHTGERPYECSKCGRAFSRSSDLSKH 466

  Fly   202 K---TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLT 263
            |   |..:.:.|.:|...||..|.|..|...|.:...:||..|...|.:....||| .:||....
Human   467 KRIHTREKHYGCPQCGKDFSIKAELTKHRRIHTEEKRYRCEECGKAFRHNCKRRAH-EREHTGEK 530

  Fly   264 QFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQ 328
            .::|..|.|..:....|..|.:.||..|.:.|..|...|:.||....|.|:||||:|::|.:|..
Human   531 PYQCRDCGKTFQDKHCLTIHQRIHTGEKPYKCLECGKAFSGKSNLTNHRRIHTGEKPHKCEVCGM 595

  Fly   329 TFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKV 393
            .|.|||||:.|.|.||||||:.|..|  ..:|.|.:.|..| |::|..:|||.||.|...|::..
Human   596 AFHHSSVLRQHKRIHTGEKPYTCSEC--GTSFRQGSALIGH-KRVHTGEKPYECEECGKAFRVSS 657

  Fly   394 ELQSHVEH----CAKCPVDGDKPSGNQSEDAQILSVLRFNMAVVLKKISSA 440
            .|..|.:.    .:...:||.:.|         ||.:..:...|:..::||
Human   658 NLTGHKKRKHQVWSTHELDGSRKS---------LSPVTVSQTSVVSILTSA 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/177 (33%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	13/24 (54%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/42 (14%)
		COG5048	<192..369	CDD:227381	64/202 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	7/21 (33%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	10/22 (45%)
		C2H2 Zn finger	323..343	CDD:275368	10/19 (53%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZNF311	XP_005249076.1	KRAB	97..157	CDD:214630
		KRAB	97..136	CDD:279668
		C2H2 Zn finger	282..302	CDD:275368
		zf-H2C2_2	294..319	CDD:290200
		COG5048	306..>633	CDD:227381	104/298 (35%)
		C2H2 Zn finger	310..330	CDD:275368
		zf-H2C2_2	323..347	CDD:290200	5/8 (63%)
		C2H2 Zn finger	338..358	CDD:275368	8/19 (42%)
		zf-H2C2_2	353..375	CDD:290200	12/21 (57%)
		C2H2 Zn finger	366..386	CDD:275368	7/20 (35%)
		C2H2 Zn finger	394..414	CDD:275368	8/19 (42%)
		zf-C2H2	420..442	CDD:278523	7/21 (33%)
		C2H2 Zn finger	422..442	CDD:275368	6/19 (32%)
		zf-H2C2_2	434..459	CDD:290200	2/24 (8%)
		C2H2 Zn finger	450..470	CDD:275368	3/19 (16%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	490..515	CDD:290200	7/24 (29%)
		C2H2 Zn finger	506..526	CDD:275368	6/20 (30%)
		zf-H2C2_2	520..541	CDD:290200	8/21 (38%)
		C2H2 Zn finger	534..554	CDD:275368	5/19 (26%)
		zf-H2C2_2	547..570	CDD:290200	7/22 (32%)
		C2H2 Zn finger	562..582	CDD:275368	7/19 (37%)
		zf-H2C2_2	574..599	CDD:290200	10/24 (42%)
		C2H2 Zn finger	590..610	CDD:275368	10/19 (53%)
		zf-H2C2_2	603..627	CDD:290200	12/25 (48%)
		C2H2 Zn finger	618..638	CDD:275368	7/22 (32%)
		zf-H2C2_2	634..653	CDD:290200	9/19 (47%)
		C2H2 Zn finger	646..664	CDD:275368	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910