DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp354b

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_038772.1	Gene:	Zfp354b / 27274	MGIID:	1351476	Length:	601	Species:	Mus musculus

Alignment Length:	428	Identity:	123/428 - (28%)
Similarity:	185/428 - (43%)	Gaps:	77/428 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 GPTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSK 100
            ||::.:|       |:....:..|:......:.......||:||        ...|.:.||.|.|
Mouse   164 GPSVGLK-------SIGKQKIAGEKTQRNSLEENSTLLSQPKLK--------TVEKRYKCSTCEK 213

  Fly   101 EFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERL 165
            .|...:.|::|:..|:.||..:||||.|::.|:..|..|..| |...|.::|.:|.|:|:....|
Mouse   214 AFIHNSSLRKHLKNHTGERLFQCKDCLKAFSQSSALIQHQRT-HTGEKPYICKECGKAFSHSASL 277

  Fly   166 RLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFN--------------------- 209
            ..|:|.|:.||.|.|..|.|.|:|...|..|...|.:.:..::|
Mouse   278 CKHLRTHTLEKSYTCKECGKSFSRRSGLFLHQKIHARENPHKYNPGRKASTSLSGCQRIHSRKKT 342

  Fly   210 --CTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELAL----RAHINQEHHKLTQ---- 264
              |.:|..:|.::::||.|...|......:||.|...|:...:|    |.|..::.::.::
Mouse   343 YLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCSECGKG 407

  Fly   265 -------------------FECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNV 310
                               :.|..|.|.:.....|..|.:.||..|...|:||...|.|.|....
Mouse   408 FTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQ 472

  Fly   311 HMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHK 375
            |.|||||||||:|..|.:||..:|.|..|.|.||||||:|||.|  .::|.|.|.|..| ::||.
Mouse   473 HQRMHTGERPYKCNECGKTFRCNSSLSNHQRTHTGEKPYRCQEC--GMSFGQSAALIQH-RRIHT 534

  Fly   376 QQKPYMCEGCHDFFKIKVELQSHVE--------HCAKC 405
            .:||:.|..|...|:....|.:|..        .|:.|
Mouse   535 GEKPFKCNTCGKSFRQSSSLIAHQRIHTGEKPYECSAC 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	53/181 (29%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/20 (45%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	11/23 (48%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	64/226 (28%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	7/25 (28%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	14/22 (64%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
Zfp354b	NP_038772.1	KRAB	14..73	CDD:214630
		KRAB	14..53	CDD:279668
		COG5048	182..585	CDD:227381	118/403 (29%)
		C2H2 Zn finger	208..228	CDD:275368	7/19 (37%)
		zf-H2C2_2	220..245	CDD:290200	10/24 (42%)
		C2H2 Zn finger	236..256	CDD:275368	9/20 (45%)
		zf-H2C2_2	248..273	CDD:290200	9/25 (36%)
		C2H2 Zn finger	264..284	CDD:275368	7/19 (37%)
		zf-C2H2	290..312	CDD:278523	8/21 (38%)
		C2H2 Zn finger	292..312	CDD:275368	7/19 (37%)
		C2H2 Zn finger	345..365	CDD:275368	6/19 (32%)
		zf-H2C2_2	357..382	CDD:290200	8/24 (33%)
		C2H2 Zn finger	373..393	CDD:275368	6/19 (32%)
		zf-H2C2_2	385..410	CDD:290200	3/24 (13%)
		C2H2 Zn finger	401..421	CDD:275368	0/19 (0%)
		C2H2 Zn finger	429..449	CDD:275368	5/19 (26%)
		zf-H2C2_2	442..466	CDD:290200	9/23 (39%)
		C2H2 Zn finger	457..477	CDD:275368	8/19 (42%)
		zf-H2C2_2	469..494	CDD:290200	14/24 (58%)
		C2H2 Zn finger	485..505	CDD:275368	8/19 (42%)
		zf-H2C2_2	497..520	CDD:290200	13/24 (54%)
		C2H2 Zn finger	513..533	CDD:275368	8/22 (36%)
		zf-H2C2_2	525..550	CDD:290200	9/25 (36%)
		C2H2 Zn finger	541..561	CDD:275368	5/19 (26%)
		zf-H2C2_2	553..578	CDD:290200	4/20 (20%)
		C2H2 Zn finger	569..589	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000