DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF658

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001304845.1	Gene:	ZNF658 / 26149	HGNCID:	25226	Length:	1059	Species:	Homo sapiens

Alignment Length:	350	Identity:	126/350 - (36%)
Similarity:	175/350 - (50%)	Gaps:	40/350 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 KHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQC 155
            |.:.|.:|.|.|..||.|..|..:|:.|:|::|.|||||:.....|:.| ...|...|.:.||.|
Human   544 KPYECVECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSFTYNSALRAH-QRIHTGEKPYECSDC 607

  Fly   156 PKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSH-------------------- 200
            .|:||....||.|.|:|:|||||.|:.|.:.||....|:.|...|
Human   608 EKTFAHNSALRAHHRIHTGEKPYECNECGRSFAHISVLKAHQRIHTGEKPYECNECGRSFTYNSA 672

  Fly   201 ---HK---TSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHIN-QE 258
               |:   |..:.:.|:.|..:|:.|:.|::|...|.....:.|:.||..||:..|||||.| ..
Human   673 LRAHQRIHTGRKPYECSDCEKTFAHNSALKIHQRIHTGEKPYECNECEKTFAHNSALRAHQNIHT 737

  Fly   259 HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQC 323
            ..||  :||..|.|.......|:||.:.||..|.:.|..|...|:|||..:.|.|:||||:||:|
Human   738 GEKL--YECSECGKTFFQKTRLSTHRRIHTGEKPYECSKCGKTFSQKSYLSGHERIHTGEKPYEC 800

  Fly   324 RICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDF 388
            .:|.:||.:.:.|.:|.|.||||||:.|..|..  .|||..||..| ::||..:|||.|..|...
Human   801 NVCGKTFVYKAALIVHQRIHTGEKPYECNQCGK--TFSQRTHLCAH-QRIHTGEKPYECNECGKT 862

  Fly   389 FKIKVELQSHVE-HCAKCPVDGDKP 412
            |.....|::|.. |      .|:||
Human   863 FADNSALRAHHRIH------TGEKP 881

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/181 (32%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	10/19 (53%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	69/203 (34%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	11/22 (50%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	8/19 (42%)
		zf-H2C2_2	309..332	CDD:290200	12/22 (55%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF658	NP_001304845.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		C2H2 Zn finger	279..296	CDD:275368
		C2H2 Zn finger	299..319	CDD:275368
		C2H2 Zn finger	328..347	CDD:275368
		C2H2 Zn finger	355..375	CDD:275368
		COG5048	371..789	CDD:227381	83/247 (34%)
		C2H2 Zn finger	389..406	CDD:275368
		C2H2 Zn finger	414..434	CDD:275368
		C2H2 Zn finger	442..462	CDD:275368
		C2H2 Zn finger	520..540	CDD:275368
		zf-H2C2_2	532..557	CDD:290200	5/12 (42%)
		C2H2 Zn finger	548..568	CDD:275368	8/19 (42%)
		zf-H2C2_2	560..585	CDD:290200	11/24 (46%)
		C2H2 Zn finger	576..596	CDD:275368	8/20 (40%)
		zf-H2C2_2	588..613	CDD:290200	9/25 (36%)
		C2H2 Zn finger	604..624	CDD:275368	10/19 (53%)
		zf-H2C2_2	616..641	CDD:290200	13/24 (54%)
		COG5048	628..1044	CDD:227381	90/264 (34%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		zf-H2C2_2	645..669	CDD:290200	3/23 (13%)
		C2H2 Zn finger	660..680	CDD:275368	1/19 (5%)
		zf-H2C2_2	672..697	CDD:290200	5/24 (21%)
		C2H2 Zn finger	688..708	CDD:275368	6/19 (32%)
		zf-H2C2_2	700..725	CDD:290200	7/24 (29%)
		C2H2 Zn finger	716..736	CDD:275368	11/19 (58%)
		C2H2 Zn finger	744..764	CDD:275368	6/19 (32%)
		zf-H2C2_2	757..781	CDD:290200	9/23 (39%)
		C2H2 Zn finger	772..792	CDD:275368	8/19 (42%)
		zf-H2C2_2	784..809	CDD:290200	12/24 (50%)
		C2H2 Zn finger	800..820	CDD:275368	7/19 (37%)
		zf-H2C2_2	812..837	CDD:290200	12/26 (46%)
		C2H2 Zn finger	828..848	CDD:275368	8/22 (36%)
		zf-H2C2_2	844..864	CDD:290200	8/20 (40%)
		C2H2 Zn finger	856..876	CDD:275368	5/19 (26%)
		zf-H2C2_2	868..892	CDD:290200	5/19 (26%)
		C2H2 Zn finger	884..903	CDD:275368
		C2H2 Zn finger	912..932	CDD:275368
		C2H2 Zn finger	940..960	CDD:275368
		zf-H2C2_2	953..977	CDD:290200
		C2H2 Zn finger	968..988	CDD:275368
		zf-H2C2_2	980..1005	CDD:290200
		C2H2 Zn finger	996..1016	CDD:275368
		zf-H2C2_2	1009..1033	CDD:290200
		C2H2 Zn finger	1024..1045	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910