DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZNF473

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001006657.1	Gene:	ZNF473 / 25888	HGNCID:	23239	Length:	871	Species:	Homo sapiens

Alignment Length:	519	Identity:	138/519 - (26%)
Similarity:	196/519 - (37%)	Gaps:	131/519 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RSRRSVSKEDAVSLLTDSGISLSSPPAARESSPGPTLAIKRRKSSLASLRDACVDEEEDDGGEQD 67
            |.|...||..|...|....|......||:.:|.........|.|||      .::.:....||:.
Human   344 RKRYECSKCQATFNLRKHLIQHQKTHAAKTTSECQECGKIFRHSSL------LIEHQALHAGEEP 402

  Fly    68 SKDDDYVQPQLKKSARKGEPVK--------RKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCK 124
            .|.:     :..||.|....:|        .|.:.||:|.|.|...|.|..|..||:..|||||:
Human   403 YKCN-----ERGKSFRHNSTLKIHQRVHSGEKPYKCSECGKAFHRHTHLNEHRRIHTGYRPHKCQ 462

  Fly   125 DCGKSYRQAVNLKNH--ITTA-------------------------------------------- 143
            :|.:|:.:..:|..|  |.||
Human   463 ECVRSFSRPSHLMRHQAIHTAEKPYSCAECKETFSDNNRLVQHQKMHTVKTPYECQECGERFICG 527

  Fly   144 ---------HEHRKQ-------------------FVCSQCPKSFALKERLRLHMRLHS-GEKPYP 179
                     |...||                   |.|::|.|:|:..:.|..|.|:|: |.||:.
Human   528 STLKCHESVHAREKQGFFVSGKILDQNPEQKEKCFKCNKCEKTFSCSKYLTQHERIHTRGVKPFE 592

  Fly   180 CDLCDKKFARGGQLQQHMVSHHK-------------------------TSIQQFNCTKCSASFST 219
            ||.|.|.|.:..:|..|...|.:                         |....|.|.:|..:||.
Human   593 CDQCGKAFGQSTRLIHHQRIHSRVRLYKWGEQGKAISSASLIKLQSFHTKEHPFKCNECGKTFSH 657

  Fly   220 NANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHM 284
            :|:|..|...|......:||.|:..|.....|..| .:.|.:.....|..|.|.......|:.|.
Human   658 SAHLSKHQLIHAGENPFKCSKCDRVFTQRNYLVQH-ERTHARKKPLVCNECGKTFRQSSCLSKHQ 721

  Fly   285 QRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPF 349
            :.|:..|.:||:.|...|...::...|.|:||||:||.|:.|.:.|..||.|.:|.|.||||||:
Human   722 RIHSGEKPYVCDYCGKAFGLSAELVRHQRIHTGEKPYVCQECGKAFTQSSCLSIHRRVHTGEKPY 786

  Fly   350 RCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE--------HCAKC 405
            ||..|..  ||:|.|:|..| ::||..:|||.|..|...|.:...|..|:.        .|.:|
Human   787 RCGECGK--AFAQKANLTQH-QRIHTGEKPYSCNVCGKAFVLSAHLNQHLRVHTQETLYQCQRC 847

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	61/266 (23%)
		C2H2 Zn finger	95..115	CDD:275368	8/19 (42%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/75 (11%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/24 (50%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	61/201 (30%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	8/19 (42%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	4/16 (25%)
ZNF473	NP_001006657.1	KRAB_A-box	6..45	CDD:143639
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	47..81
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	140..164
		COG5048	207..614	CDD:227381	66/280 (24%)
		C2H2 Zn finger	211..231	CDD:275368
		C2H2 Zn finger	239..259	CDD:275368
		C2H2 Zn finger	267..286	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	290..318
		Interaction with SLBP/pre-mRNA complex	312..552		47/218 (22%)
		C2H2 Zn finger	322..342	CDD:275368
		C2H2 Zn finger	349..369	CDD:275368	5/19 (26%)
		C2H2 Zn finger	377..397	CDD:275368	4/25 (16%)
		C2H2 Zn finger	405..425	CDD:275368	4/24 (17%)
		C2H2 Zn finger	433..453	CDD:275368	8/19 (42%)
		COG5048	457..860	CDD:227381	106/395 (27%)
		C2H2 Zn finger	461..481	CDD:275368	5/19 (26%)
		C2H2 Zn finger	489..509	CDD:275368	0/19 (0%)
		C2H2 Zn finger	517..537	CDD:275368	0/19 (0%)
		C2H2 Zn finger	564..584	CDD:275368	7/19 (37%)
		C2H2 Zn finger	593..613	CDD:275368	7/19 (37%)
		C2H2 Zn finger	648..668	CDD:275368	7/19 (37%)
		C2H2 Zn finger	676..696	CDD:275368	6/20 (30%)
		C2H2 Zn finger	704..724	CDD:275368	5/19 (26%)
		C2H2 Zn finger	732..752	CDD:275368	5/19 (26%)
		C2H2 Zn finger	760..780	CDD:275368	8/19 (42%)
		C2H2 Zn finger	788..808	CDD:275368	8/22 (36%)
		C2H2 Zn finger	816..836	CDD:275368	5/19 (26%)
		C2H2 Zn finger	844..864	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910