DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp647

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001161748.1	Gene:	Zfp647 / 239546	MGIID:	3052806	Length:	535	Species:	Mus musculus

Alignment Length:	398	Identity:	127/398 - (31%)
Similarity:	185/398 - (46%)	Gaps:	43/398 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 GISLSSPPAARESSPG---PTLAIK-----RRKSSLASLRDACVDEEEDDGGEQDSKDDDYV--- 74
            |::.|.|.|..:::|.   |.:.|:     .|.|.|       :..:....||:     .||
Mouse   154 GLNPSVPVARPQTAPSVERPYICIECGKCFGRSSHL-------LQHQRIHTGEK-----PYVCHV 206

  Fly    75 -------QPQLKKSAR--KGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSY 130
                   ...|.|..|  .||    |.:.|::|.|.|...:||.:|..||:.|:||:|.:|||::
Mouse   207 CGKAFSQSSVLSKHRRIHTGE----KPYECNECGKAFRVSSDLAQHHKIHTGEKPHECLECGKAF 267

  Fly   131 RQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQ 195
            .|..:|..| ...|...:.:||..|.|:|.....||.|.|:|:||||:.|..|.|.|:....|.|
Mouse   268 TQLSHLIQH-QRIHTGERPYVCPLCGKAFNHSTVLRSHQRVHTGEKPHGCSECGKTFSVKRTLLQ 331

  Fly   196 HMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHH 260
            |...|  |..:.:.|::|..:||..:.|..|...|.....:.||.|...|::...|..| .:.|.
Mouse   332 HQRVH--TGEKPYTCSECGKAFSDRSVLIQHHNVHTGEKPYECSECGKTFSHRSTLMNH-ERIHT 393

  Fly   261 KLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRI 325
            :...:.|..|.|.......|..|.:.||..|.:||..|...|:.:.....|.|:||||:|:||..
Mouse   394 QEKPYACYECGKAFVQHSHLIQHQRVHTGEKPYVCGECGHAFSARRSLIQHERIHTGEKPFQCTE 458

  Fly   326 CHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFK 390
            |.:.|:..:.|.:|:|.||||||:.|..|..  ||||.:.|..| ::||..:|||.|..|...|.
Mouse   459 CGKAFSLKATLIVHLRTHTGEKPYECNSCGK--AFSQYSVLIQH-QRIHTGEKPYECGECGRAFN 520

  Fly   391 IKVELQSH 398
            ....|..|
Mouse   521 QHGHLIQH 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
Zfp647	NP_001161748.1	KRAB	17..77	CDD:214630
		COG5048	172..512	CDD:227381	117/362 (32%)
		C2H2 Zn finger	176..196	CDD:275368	4/26 (15%)
		C2H2 Zn finger	204..224	CDD:275368	3/19 (16%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..280	CDD:275368	7/20 (35%)
		C2H2 Zn finger	288..308	CDD:275368	8/19 (42%)
		C2H2 Zn finger	316..336	CDD:275368	7/19 (37%)
		C2H2 Zn finger	344..364	CDD:275368	6/19 (32%)
		C2H2 Zn finger	372..392	CDD:275368	6/20 (30%)
		C2H2 Zn finger	400..420	CDD:275368	5/19 (26%)
		C2H2 Zn finger	428..448	CDD:275368	5/19 (26%)
		C2H2 Zn finger	456..476	CDD:275368	6/19 (32%)
		C2H2 Zn finger	484..504	CDD:275368	8/22 (36%)
		C2H2 Zn finger	512..532	CDD:275368	5/17 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910