DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and ZKSCAN5

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001305011.1	Gene:	ZKSCAN5 / 23660	HGNCID:	12867	Length:	839	Species:	Homo sapiens

Alignment Length:	525	Identity:	127/525 - (24%)
Similarity:	181/525 - (34%)	Gaps:	187/525 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 PTLAIKRRKSSLASLRDACVDEEEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKE 101
            ||:...|:..|.....||..|                :.|   |.:..||    :.|.||.|.|.
Human   313 PTVGKSRQNPSQKRDLDAITD----------------ISP---KQSTHGE----RGHRCSDCGKF 354

  Fly   102 FGGKTDLQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLR 166
            |...::..:|..||:.|:|.||.:|||||.|.|:|..| ...|...|.:.|..|.|:|.:...|.
Human   355 FLQASNFIQHRRIHTGEKPFKCGECGKSYNQRVHLTQH-QRVHTGEKPYKCQVCGKAFRVSSHLV 418

  Fly   167 LHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHK----------------------------- 202
            .|..:||||:||.|:.|.|.|.|...|.:|:..|.:
Human   419 QHHSVHSGERPYGCNECGKNFGRHSHLIEHLKRHFREKSQRCSDKRSKNTKLSVKKKISEYSEAD 483

  Fly   203 -----------TSIQQF------------------------------------------------ 208
                       :.:|.|
Human   484 MELSGKTQRNVSQVQDFGEGCEFQGKLDRKQGIPMKEILGQPSSKRMNYSEVPYVHKKSSTGERP 548

  Fly   209 -NCTKCSASFSTNANL------------------------RVHMERHEQ----GMEHRCSICENQ 244
             .|.:|..||..:|:|                        |||:.:|::    ...:.|.:|...
Human   549 HKCNECGKSFIQSAHLIQHQRIHTGEKPFRCEECGKSYNQRVHLTQHQRVHTGEKPYTCPLCGKA 613

  Fly   245 FANELALRAHINQE---HHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKS 306
            |    .:|:|:.|.   |.....|:|..|.|.......||.|::.|:..|:|.|..|...|.|..
Human   614 F----RVRSHLVQHQSVHSGERPFKCNECGKGFGRRSHLAGHLRLHSREKSHQCRECGEIFFQYV 674

  Fly   307 QYNVHMRMHTG----------------------------ERPYQCRICHQTFAHSSVLKLHIRKH 343
            ....|..:|.|                            |:||||.||.:.|.:||.|..|.|.|
Human   675 SLIEHQVLHMGQKNEKNGICEEAYSWNLTVIEDKKIELQEQPYQCDICGKAFGYSSDLIQHYRTH 739

  Fly   344 TGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSHVE-------- 400
            |.|||::|.:|.:.|  .|.:|.|.| :||:...|.:.|..|...|.:|..|..|..
Human   740 TAEKPYQCDICRENV--GQCSHTKQH-QKIYSSTKSHQCHECGRGFTLKSHLNQHQRIHTGEKPF 801

  Fly   401 HCAKC 405
            .|.:|
Human   802 QCKEC 806

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	59/275 (21%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	10/20 (50%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	63/324 (19%)
		C2H2 Zn finger	210..230	CDD:275370	9/43 (21%)
		C2H2 Zn finger	238..260	CDD:275371	6/24 (25%)
		C2H2 Zn finger	267..287	CDD:275368	6/19 (32%)
		C2H2 Zn finger	295..315	CDD:275368	5/19 (26%)
		zf-H2C2_2	309..332	CDD:290200	11/50 (22%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
ZKSCAN5	NP_001305011.1	SCAN	46..155	CDD:128708
		SCAN	47..134	CDD:280241
		KRAB	222..257	CDD:279668
		COG5048	318..762	CDD:227381	112/473 (24%)
		C2H2 Zn finger	348..368	CDD:275368	6/19 (32%)
		zf-H2C2_2	360..385	CDD:290200	12/24 (50%)
		C2H2 Zn finger	376..396	CDD:275368	10/20 (50%)
		zf-H2C2_2	388..411	CDD:290200	7/23 (30%)
		C2H2 Zn finger	404..424	CDD:275368	6/19 (32%)
		C2H2 Zn finger	432..452	CDD:275368	7/19 (37%)
		zf-C2H2	549..571	CDD:278523	6/21 (29%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		zf-H2C2_2	563..588	CDD:290200	1/24 (4%)
		C2H2 Zn finger	579..599	CDD:275368	4/19 (21%)
		zf-H2C2_2	591..614	CDD:290200	4/22 (18%)
		C2H2 Zn finger	607..627	CDD:275368	6/23 (26%)
		zf-H2C2_2	619..644	CDD:290200	7/24 (29%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		C2H2 Zn finger	663..683	CDD:275368	5/19 (26%)
		zf-C2H2	717..739	CDD:278523	11/21 (52%)
		C2H2 Zn finger	719..739	CDD:275368	9/19 (47%)
		C2H2 Zn finger	747..795	CDD:275368	16/50 (32%)
		COG5048	758..>823	CDD:227381	14/50 (28%)
		zf-C2H2	773..795	CDD:278523	6/21 (29%)
		zf-H2C2_2	787..811	CDD:290200	4/20 (20%)
		C2H2 Zn finger	803..823	CDD:275368	2/4 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910