DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp51

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001295252.1	Gene:	Zfp51 / 22709	MGIID:	99198	Length:	781	Species:	Mus musculus

Alignment Length:	430	Identity:	135/430 - (31%)
Similarity:	200/430 - (46%)	Gaps:	66/430 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 CVDEEEDD---GGEQDSKD--DDY-------VQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTD 107
            |.|..:|.   ..:|..::  |||       :||...        :|.|.|.|.:|.|.|...:.
Mouse   172 CSDISQDQRLYNAKQHRQEVYDDYFSSAYSLMQPTAY--------IKEKPHQCGKCGKCFNTSSS 228

  Fly   108 LQRHMLIHSDERPHKCKDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLH 172
            |..|..||:.|:|:||..|.||:.|..:||.| ...|...|.:.|.:|.|||.....|:.|.:||
Mouse   229 LTVHHRIHTKEKPYKCSVCDKSFTQCTHLKIH-QRRHTGEKPYKCKECEKSFVQLSALKSHQKLH 292

  Fly   173 SGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHR 237
            :|||||.|..|||.||.....:.|...|  ||.:..:|.:|...|...::||.|...|.....::
Mouse   293 TGEKPYKCKECDKSFAHYPNFRTHQKIH--TSEEHCSCPECGREFHQLSHLRKHYRLHTGEKPYK 355

  Fly   238 CSICENQFANELALRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYF 302
            |:.|:..|.:..:||.| .:.|.....:||:.|.|.......|..|.:.||..|.:.||:|:..|
Mouse   356 CNECDRSFTHYASLRWH-QKTHTPEIHYECKECGKSFIELSHLKRHYRIHTGEKPYKCEICDKSF 419

  Fly   303 TQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLC------------- 354
            |..:....|.::||||:||:||.|.::|.|||.|:.|...||||:|:||:.|
Mouse   420 TTTTTLKTHQKIHTGEKPYKCRECDKSFIHSSHLRRHQNVHTGERPYRCKECDKSFHESATLREH 484

  Fly   355 -------------EDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH-VEHCAKC 405
                         |.:.:|:|.|:|:||..::|..::||.|:.|...|.....|:.| ..|..|.
Mouse   485 EKSHTGEKTYKCRECDKSFTQRAYLRNHHNRVHTGERPYECKECGKSFTTCSTLRIHQTIHTGKK 549

  Fly   406 P---VDGDKPSGNQSEDAQILSVLRFNMAVVLKKISSAQK 442
            |   ::..|...|.       |.||.:     :|:.|.:|
Mouse   550 PYKCIECGKSFTNN-------SYLRTH-----QKVHSGEK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	58/158 (37%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	11/24 (46%)
		C2H2 Zn finger	123..144	CDD:275368	8/20 (40%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	14/23 (61%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	61/202 (30%)
		C2H2 Zn finger	210..230	CDD:275370	6/19 (32%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	9/19 (47%)
		C2H2 Zn finger	351..374	CDD:275368	9/48 (19%)
		C2H2 Zn finger	382..399	CDD:275368	5/17 (29%)
Zfp51	NP_001295252.1	KRAB	42..82	CDD:366587
		C2H2 Zn finger	216..236	CDD:275368	6/19 (32%)
		SFP1	<239..318	CDD:227516	34/79 (43%)
		C2H2 Zn finger	244..264	CDD:275368	8/20 (40%)
		C2H2 Zn finger	272..292	CDD:275368	7/19 (37%)
		C2H2 Zn finger	300..320	CDD:275368	7/19 (37%)
		COG5048	327..749	CDD:227381	78/264 (30%)
		C2H2 Zn finger	356..376	CDD:275368	6/20 (30%)
		C2H2 Zn finger	384..404	CDD:275368	5/19 (26%)
		C2H2 Zn finger	412..432	CDD:275368	6/19 (32%)
		C2H2 Zn finger	440..460	CDD:275368	9/19 (47%)
		C2H2 Zn finger	468..488	CDD:275368	2/19 (11%)
		C2H2 Zn finger	496..517	CDD:275368	7/20 (35%)
		C2H2 Zn finger	525..545	CDD:275368	5/19 (26%)
		C2H2 Zn finger	553..573	CDD:275368	6/31 (19%)
		C2H2 Zn finger	581..601	CDD:275368
		C2H2 Zn finger	609..629	CDD:275368
		C2H2 Zn finger	637..657	CDD:275368
		C2H2 Zn finger	665..685	CDD:275368
		C2H2 Zn finger	693..713	CDD:275368
		C2H2 Zn finger	721..741	CDD:275368
		C2H2 Zn finger	749..769	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000