DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp27

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_001032796.1	Gene:	Zfp27 / 22689	MGIID:	99174	Length:	819	Species:	Mus musculus

Alignment Length:	357	Identity:	119/357 - (33%)
Similarity:	168/357 - (47%)	Gaps:	35/357 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 RKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKCKDCGKSYRQ--AVNLKNHITTA-- 143
            ||...::.|..:|::|.|.|..:::|..|...|:.|:|::|.||||::.|  |:.:...|.|.
Mouse   391 RKKVQMREKSSICAECGKAFTYRSELIIHQRTHTGEKPYQCGDCGKAFTQKSALTVHRRIHTGEK 455

  Fly   144 -----------------------HEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDK 185
                                   |...|.:.|..|.|.|..|.:|.:|.|:|:|||||.|..|.|
Mouse   456 SYVCVKCGLAFVQRAHLDAHQVIHTGEKPYQCGHCGKFFTSKSQLHVHKRIHTGEKPYVCSNCGK 520

  Fly   186 KFARGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELA 250
            .||....|..|..:|  |..:.:.|.:|..:|:..::|..|...|.....:.||.|...|..:..
Mouse   521 AFANRSNLITHQKTH--TGEKAYVCARCGKAFTQRSDLVTHQRIHTGEKPYGCSTCGKAFTQKSH 583

  Fly   251 LRAHINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMH 315
            |..| .:.|....|:.|..|.|.......|..|.:.||..|.|||..|...|.:||.:..|.|:|
Mouse   584 LSIH-EKIHTGERQYGCRDCGKAFNQKSILIVHQKIHTGEKPHVCAECGRAFIRKSNFITHQRIH 647

  Fly   316 TGERPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPY 380
            |||:||.|..|.::|...|.|.:|...||||||:.|..|..  |||..::|..| :|.|..:|||
Mouse   648 TGEKPYGCTDCGKSFTSKSQLLVHRPIHTGEKPYVCAECGK--AFSGRSNLSKH-QKTHTGEKPY 709

  Fly   381 MCEGCHDFFKIKVELQSHVE-HCAKCPVD-GD 410
            .|..|...|:.|.||.:|.. |..:.|.| ||
Mouse   710 ACSECGKSFRQKSELITHHRIHTGEKPYDCGD 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/185 (29%)
		C2H2 Zn finger	95..115	CDD:275368	6/19 (32%)
		zf-H2C2_2	107..132	CDD:290200	10/24 (42%)
		C2H2 Zn finger	123..144	CDD:275368	9/47 (19%)
		C2H2 Zn finger	152..172	CDD:275368	8/19 (42%)
		zf-H2C2_2	165..189	CDD:290200	13/23 (57%)
		C2H2 Zn finger	180..200	CDD:275368	7/19 (37%)
		COG5048	<192..369	CDD:227381	59/176 (34%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	6/19 (32%)
		C2H2 Zn finger	351..374	CDD:275368	8/22 (36%)
		C2H2 Zn finger	382..399	CDD:275368	6/16 (38%)
Zfp27	NP_001032796.1	KRAB	2..37	CDD:366587
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	93..123
		C2H2 Zn finger	152..171	CDD:275370
		C2H2 Zn finger	179..199	CDD:275368
		C2H2 Zn finger	207..227	CDD:275368
		COG5048	<212..372	CDD:227381
		C2H2 Zn finger	235..255	CDD:275368
		C2H2 Zn finger	263..283	CDD:275368
		C2H2 Zn finger	291..311	CDD:275368
		COG5048	317..746	CDD:227381	119/357 (33%)
		C2H2 Zn finger	319..339	CDD:275368
		C2H2 Zn finger	347..367	CDD:275368
		C2H2 Zn finger	403..423	CDD:275368	6/19 (32%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	0/19 (0%)
		C2H2 Zn finger	487..507	CDD:275368	8/19 (42%)
		C2H2 Zn finger	515..535	CDD:275368	7/19 (37%)
		C2H2 Zn finger	543..563	CDD:275368	5/19 (26%)
		C2H2 Zn finger	571..591	CDD:275368	6/20 (30%)
		C2H2 Zn finger	599..619	CDD:275368	5/19 (26%)
		C2H2 Zn finger	627..647	CDD:275368	7/19 (37%)
		C2H2 Zn finger	655..675	CDD:275368	6/19 (32%)
		C2H2 Zn finger	683..703	CDD:275368	8/22 (36%)
		C2H2 Zn finger	711..731	CDD:275368	7/19 (37%)
		C2H2 Zn finger	739..759	CDD:275368	2/3 (67%)
		zf-H2C2_2	752..775	CDD:372612
		C2H2 Zn finger	767..787	CDD:275368
		zf-H2C2_2	779..804	CDD:372612
		C2H2 Zn finger	795..815	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910