DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp11

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_766050.1	Gene:	Zfp11 / 22648	MGIID:	99156	Length:	647	Species:	Mus musculus

Alignment Length:	402	Identity:	116/402 - (28%)
Similarity:	176/402 - (43%)	Gaps:	64/402 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 DDGGEQDSKDDDYVQPQLKKSARK-------GEPVK-----RKHHV---------CSQCSKEFGG 104
            |:.|...||.....|.|:..:..|       |:..:     .:||:         |.:|.|.|..
Mouse   200 DECGRAFSKHSSLTQHQVIHTGEKPYQCRECGKAFRYQSTLTRHHIVHTGAKPYKCPECDKAFNN 264

  Fly   105 KTDLQRHMLIHSDERPHK----------------------------CKDCGKSYRQAVNLKNHIT 141
            .:.|.||.:||:.|:|:|                            |::|||.:|.:..|..| .
Mouse   265 SSTLSRHQIIHTGEKPYKCQECGRAFYCSSFLIQHMKIHFEEMPYRCRECGKPFRLSSQLIRH-Q 328

  Fly   142 TAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFARGGQLQQHMVSHHKTSIQ 206
            ..|...:.::|.:|.|:|..:..|..|..||:|.|||.|..|.|.|.....|.:|.:.|  |..:
Mouse   329 RIHTGEEPYICRECGKTFKYQSNLTRHQILHTGAKPYKCPECGKAFNNSSTLTRHQIIH--TGEK 391

  Fly   207 QFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRAHINQEHHKLTQFECEICH 271
            .:.|.:||.:|..::.|..||:.|.:.:.:||..|...|.....|..| .:.|.....:.|:.|.
Mouse   392 PYKCQECSKAFYCSSYLIQHMKIHFEEIPYRCKECGKPFKCSSQLIRH-QRIHSGEKPYICKECG 455

  Fly   272 KMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGERPYQCRICHQTFAHSSVL 336
            |.......|..|.:.||..|.:||:.|...|...|..:.|.|:|.|:|.|:|:.|.:.:..||.|
Mouse   456 KAFNCTSYLTKHQRIHTGEKPYVCQECGKAFNCSSYLSKHQRIHIGDRLYKCKECGKAYYFSSQL 520

  Fly   337 KLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCEGCHDFFKIKVELQSH--- 398
            ..|.|.||||||:.||.|..  ||:..::|..| ::||..:|||:|:.|...|.....|..|
Mouse   521 NRHQRIHTGEKPYVCQECGK--AFNCSSYLTKH-QRIHIVEKPYVCKECSKAFSCSSYLTKHQRI 582

  Fly   399 -----VEHCAKC 405
                 :..|.:|
Mouse   583 HAGDRLYKCTEC 594

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	54/200 (27%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/52 (23%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	6/19 (32%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	57/176 (32%)
		C2H2 Zn finger	210..230	CDD:275370	7/19 (37%)
		C2H2 Zn finger	238..260	CDD:275371	5/21 (24%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	6/19 (32%)
		zf-H2C2_2	309..332	CDD:290200	8/22 (36%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/24 (21%)
Zfp11	NP_766050.1	C2H2 Zn finger	59..79	CDD:275368
		COG5048	83..460	CDD:227381	68/263 (26%)
		C2H2 Zn finger	87..107	CDD:275368
		C2H2 Zn finger	115..135	CDD:275368
		zf-H2C2_2	128..152	CDD:290200
		C2H2 Zn finger	143..163	CDD:275368
		C2H2 Zn finger	171..191	CDD:275368
		C2H2 Zn finger	199..219	CDD:275368	6/18 (33%)
		C2H2 Zn finger	227..247	CDD:275368	3/19 (16%)
		C2H2 Zn finger	255..275	CDD:275368	7/19 (37%)
		C2H2 Zn finger	283..303	CDD:275368	0/19 (0%)
		DUF45	<308..349	CDD:302795	12/41 (29%)
		C2H2 Zn finger	311..331	CDD:275368	7/20 (35%)
		COG5048	335..>645	CDD:227381	86/266 (32%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		C2H2 Zn finger	367..387	CDD:275368	6/19 (32%)
		C2H2 Zn finger	395..415	CDD:275368	7/19 (37%)
		C2H2 Zn finger	423..443	CDD:275368	5/20 (25%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		zf-H2C2_2	463..488	CDD:290200	9/24 (38%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	507..527	CDD:275368	7/19 (37%)
		zf-H2C2_2	520..544	CDD:290200	14/25 (56%)
		C2H2 Zn finger	535..555	CDD:275368	7/22 (32%)
		C2H2 Zn finger	563..583	CDD:275368	5/19 (26%)
		C2H2 Zn finger	591..611	CDD:275368	2/4 (50%)
		zf-H2C2_2	604..628	CDD:290200
		C2H2 Zn finger	619..639	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000