DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11247 and Zfp3

DIOPT Version :9

Sequence 1:	NP_001097659.1	Gene:	CG11247 / 40414	FlyBaseID:	FBgn0037120	Length:	522	Species:	Drosophila melanogaster
Sequence 2:	NP_808233.1	Gene:	Zfp3 / 193043	MGIID:	99177	Length:	497	Species:	Mus musculus

Alignment Length:	476	Identity:	141/476 - (29%)
Similarity:	214/476 - (44%)	Gaps:	49/476 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVRSRRSVSKEDAVSLL----TDSGISLSSPPAARESSPGPTLAI---KRRKSSLASLRDACVDE 58
            ::..|....:..|..||    :.||...|..|  |..:|.|::..   ..|.|:.|:....|:..
Mouse    58 IIEKRYPQERHFASGLLIFKKSSSGEKTSENP--RGFNPNPSVLCHGGAERASACAASGHNCLGS 120

  Fly    59 EEDDGGEQDSKDDDYVQPQLKKSARKGEPVKRKHHVCSQCSKEFGGKTDLQRHMLIHSDERPHKC 123
            .|                 |.|:  :|.||..|.|.|.:|.|.|...:.|.:||.:||.|:|.:|
Mouse   121 IE-----------------LTKA--QGPPVGEKPHTCKECGKAFNQNSHLIQHMRVHSGEKPFEC 166

  Fly   124 KDCGKSYRQAVNLKNHITTAHEHRKQFVCSQCPKSFALKERLRLHMRLHSGEKPYPCDLCDKKFA 188
            |:|||::....:|:.| ...|...|.|.|::|.|:|.....|..|.|:|:||:||.|:.|.|.|:
Mouse   167 KECGKTFGTNSSLRRH-QRIHAGEKPFACTECGKAFIQSSHLIHHHRIHTGERPYKCEECGKAFS 230

  Fly   189 RGGQLQQHMVSHHKTSIQQFNCTKCSASFSTNANLRVHMERHEQGMEHRCSICENQFANELALRA 253
            :...|..|...|  |..:.:.|.:|..:|..::.|..|...|.:...|.||.|...|.:...|..
Mouse   231 QNSALILHQRIH--TGEKPYECNECGKTFRVSSQLIQHQRIHTEERYHECSECGKAFKHSSGLIR 293

  Fly   254 HINQEHHKLTQFECEICHKMIEPDEDLATHMQRHTAVKTHVCEVCNTYFTQKSQYNVHMRMHTGE 318
            | .:.|.....:.|..|.|......:|..|.:.||..|.:.|..|...|.|.|:...|:|:||||
Mouse   294 H-QKIHTGEKPYLCNECGKGFGQSSELIRHQRIHTGDKPYECSECGKTFGQNSEIIRHIRIHTGE 357

  Fly   319 RPYQCRICHQTFAHSSVLKLHIRKHTGEKPFRCQLCEDEVAFSQLAHLKNHMKKIHKQQKPYMCE 383
            :||.|:.|.:.|..:|.|..|.|.||||||:.|..|..  ||.:.:||..| ::||..:||:.|.
Mouse   358 KPYVCKECGKAFRGNSELLRHERIHTGEKPYECFECGK--AFRRTSHLIVH-QRIHTGEKPHQCN 419

  Fly   384 GCHDFFKIKVELQSHVE-HCAKCPVDGDKPSGNQSEDAQILSVLRFNMAVVLKKISSAQKLRQLG 447
            .|...|....||..|.: |..:.|.:..:.....|:.:|:         .:.::|.:.:|    .
Mouse   420 ECARTFWDNSELLLHQKIHIGEKPYECSECEKTFSQHSQL---------TIHQRIHTGEK----P 471

  Fly   448 YEKRLIDNVIIASLKLAQRQS 468
            ||.:........|..|.:.||
Mouse   472 YECQECQKTFSRSSHLLRHQS 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11247	NP_001097659.1	COG5048	<88..247	CDD:227381	55/158 (35%)
		C2H2 Zn finger	95..115	CDD:275368	7/19 (37%)
		zf-H2C2_2	107..132	CDD:290200	12/24 (50%)
		C2H2 Zn finger	123..144	CDD:275368	7/20 (35%)
		C2H2 Zn finger	152..172	CDD:275368	7/19 (37%)
		zf-H2C2_2	165..189	CDD:290200	12/23 (52%)
		C2H2 Zn finger	180..200	CDD:275368	6/19 (32%)
		COG5048	<192..369	CDD:227381	58/176 (33%)
		C2H2 Zn finger	210..230	CDD:275370	5/19 (26%)
		C2H2 Zn finger	238..260	CDD:275371	6/21 (29%)
		C2H2 Zn finger	267..287	CDD:275368	5/19 (26%)
		C2H2 Zn finger	295..315	CDD:275368	7/19 (37%)
		zf-H2C2_2	309..332	CDD:290200	11/22 (50%)
		C2H2 Zn finger	323..343	CDD:275368	7/19 (37%)
		C2H2 Zn finger	351..374	CDD:275368	7/22 (32%)
		C2H2 Zn finger	382..399	CDD:275368	5/16 (31%)
Zfp3	NP_808233.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		COG5048	134..494	CDD:227381	120/379 (32%)
		zf-C2H2	136..158	CDD:278523	8/21 (38%)
		C2H2 Zn finger	138..158	CDD:275368	7/19 (37%)
		zf-H2C2_2	150..175	CDD:290200	12/24 (50%)
		C2H2 Zn finger	166..186	CDD:275368	7/20 (35%)
		zf-H2C2_2	178..203	CDD:290200	9/25 (36%)
		C2H2 Zn finger	194..214	CDD:275368	7/19 (37%)
		zf-H2C2_2	206..231	CDD:290200	12/24 (50%)
		C2H2 Zn finger	222..242	CDD:275368	6/19 (32%)
		zf-H2C2_2	238..257	CDD:290200	5/20 (25%)
		C2H2 Zn finger	250..270	CDD:275368	5/19 (26%)
		C2H2 Zn finger	278..298	CDD:275368	6/20 (30%)
		zf-H2C2_2	291..313	CDD:290200	6/22 (27%)
		C2H2 Zn finger	306..326	CDD:275368	5/19 (26%)
		zf-H2C2_2	318..341	CDD:290200	7/22 (32%)
		C2H2 Zn finger	334..354	CDD:275368	7/19 (37%)
		zf-H2C2_2	349..369	CDD:290200	10/19 (53%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	374..399	CDD:290200	13/26 (50%)
		C2H2 Zn finger	390..410	CDD:275368	7/22 (32%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	430..455	CDD:290200	5/24 (21%)
		C2H2 Zn finger	446..466	CDD:275368	2/28 (7%)
		zf-H2C2_2	459..483	CDD:290200	4/36 (11%)
		C2H2 Zn finger	474..494	CDD:275368	4/19 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000